Pi-Pi contacts are an overlooked protein feature relevant to phase separation

Pi-Pi contacts are an overlooked protein feature relevant to phase separation

Protein phase separation is implicated in formation of membraneless organelles, signaling puncta and the nuclear pore. Multivalent interactions of modular binding domains and their target motifs can drive phase separation. However, forces promoting the more common phase separation of intrinsically d...

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Bibliographic Details
Main Authors: Robert McCoy Vernon, Paul Andrew Chong, Brian Tsang, Tae Hun Kim, Alaji Bah, Patrick Farber, Hong Lin, Julie Deborah Forman-Kay
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
protein phase separation
protein interactions
pi interactions
protein structure
prediction
bioinformatics
Online Access:https://elifesciences.org/articles/31486

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