A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration
Pulmonary drug delivery has recognized benefits for both local and systemic treatments. Dry powder inhalers (DPIs) are convenient, portable and environmentally friendly devices, becoming an optimal choice for patients. The tailoring of novel formulations for DPIs, namely in the form of porous partic...
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doaj-61b488db841042a8bb6adf757797263f2021-05-04T06:06:18ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-05-01910.3389/fbioe.2021.671381671381A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug AdministrationThoa Duong0Clara López-Iglesias1Piotr K. Szewczyk2Urszula Stachewicz3Joana Barros4Carmen Alvarez-Lorenzo5Mohammad Alnaief6Carlos A. García-González7Department of Pharmacology, Pharmacy and Pharmaceutical Technology, I+D Farma group (GI-1645), Faculty of Pharmacy, and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, SpainDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, I+D Farma group (GI-1645), Faculty of Pharmacy, and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, SpainFaculty of Metals Engineering and Industrial Computer Science, AGH University of Science and Technology, Krakow, PolandFaculty of Metals Engineering and Industrial Computer Science, AGH University of Science and Technology, Krakow, Polandi3S – Instituto de Investigação e Inovação em Saúde da Universidade do Porto – Associação, INEB – Instituto de Engenharia Biomédica, FEUP – Faculdade de Engenharia, Universidade do Porto, Porto, PortugalDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, I+D Farma group (GI-1645), Faculty of Pharmacy, and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, SpainDepartment of Pharmaceutical and Chemical Engineering, Faculty of Applied Medical Sciences, German Jordanian University, Amman, JordanDepartment of Pharmacology, Pharmacy and Pharmaceutical Technology, I+D Farma group (GI-1645), Faculty of Pharmacy, and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, SpainPulmonary drug delivery has recognized benefits for both local and systemic treatments. Dry powder inhalers (DPIs) are convenient, portable and environmentally friendly devices, becoming an optimal choice for patients. The tailoring of novel formulations for DPIs, namely in the form of porous particles, is stimulating in the pharmaceutical research area to improve delivery efficiency. Suitable powder technological approaches are being sought to design such formulations. Namely, aerogel powders are nanostructured porous particles with particularly attractive properties (large surface area, excellent aerodynamic properties and high fluid uptake capacity) for these purposes. In this review, the most recent development on powder technologies used for the processing of particulate porous carriers are described via updated examples and critically discussed. A special focus will be devoted to the most recent advances and uses of aerogel technology to obtain porous particles with advanced performance in pulmonary delivery.https://www.frontiersin.org/articles/10.3389/fbioe.2021.671381/fullporous particlesdry powder inhalers (DPIs)powder technologypulmonary deliveryaerogels |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thoa Duong Clara López-Iglesias Piotr K. Szewczyk Urszula Stachewicz Joana Barros Carmen Alvarez-Lorenzo Mohammad Alnaief Carlos A. García-González |
spellingShingle |
Thoa Duong Clara López-Iglesias Piotr K. Szewczyk Urszula Stachewicz Joana Barros Carmen Alvarez-Lorenzo Mohammad Alnaief Carlos A. García-González A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration Frontiers in Bioengineering and Biotechnology porous particles dry powder inhalers (DPIs) powder technology pulmonary delivery aerogels |
author_facet |
Thoa Duong Clara López-Iglesias Piotr K. Szewczyk Urszula Stachewicz Joana Barros Carmen Alvarez-Lorenzo Mohammad Alnaief Carlos A. García-González |
author_sort |
Thoa Duong |
title |
A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration |
title_short |
A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration |
title_full |
A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration |
title_fullStr |
A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration |
title_full_unstemmed |
A Pathway From Porous Particle Technology Toward Tailoring Aerogels for Pulmonary Drug Administration |
title_sort |
pathway from porous particle technology toward tailoring aerogels for pulmonary drug administration |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Bioengineering and Biotechnology |
issn |
2296-4185 |
publishDate |
2021-05-01 |
description |
Pulmonary drug delivery has recognized benefits for both local and systemic treatments. Dry powder inhalers (DPIs) are convenient, portable and environmentally friendly devices, becoming an optimal choice for patients. The tailoring of novel formulations for DPIs, namely in the form of porous particles, is stimulating in the pharmaceutical research area to improve delivery efficiency. Suitable powder technological approaches are being sought to design such formulations. Namely, aerogel powders are nanostructured porous particles with particularly attractive properties (large surface area, excellent aerodynamic properties and high fluid uptake capacity) for these purposes. In this review, the most recent development on powder technologies used for the processing of particulate porous carriers are described via updated examples and critically discussed. A special focus will be devoted to the most recent advances and uses of aerogel technology to obtain porous particles with advanced performance in pulmonary delivery. |
topic |
porous particles dry powder inhalers (DPIs) powder technology pulmonary delivery aerogels |
url |
https://www.frontiersin.org/articles/10.3389/fbioe.2021.671381/full |
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