The Complex Interplay between Metabolic Reprogramming and Epigenetic Alterations in Renal Cell Carcinoma
Renal cell carcinoma (RCC) is the most common malignancy affecting the kidney. Current therapies are mostly curative for localized disease, but do not completely preclude recurrence and metastization. Thus, it is imperative to develop new therapeutic strategies based on RCC biological properties. Pr...
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doaj-61b5fb9eceac40fdaa960cd8de060cfa2020-11-25T00:27:38ZengMDPI AGGenes2073-44252019-04-0110426410.3390/genes10040264genes10040264The Complex Interplay between Metabolic Reprogramming and Epigenetic Alterations in Renal Cell CarcinomaAna Lameirinhas0Vera Miranda-Gonçalves1Rui Henrique2Carmen Jerónimo3Cancer Biology & Epigenetics Group—Research Center, Portuguese Oncology Institute of Porto (CI-IPOP), 4200-072 Porto, PortugalCancer Biology & Epigenetics Group—Research Center, Portuguese Oncology Institute of Porto (CI-IPOP), 4200-072 Porto, PortugalCancer Biology & Epigenetics Group—Research Center, Portuguese Oncology Institute of Porto (CI-IPOP), 4200-072 Porto, PortugalCancer Biology & Epigenetics Group—Research Center, Portuguese Oncology Institute of Porto (CI-IPOP), 4200-072 Porto, PortugalRenal cell carcinoma (RCC) is the most common malignancy affecting the kidney. Current therapies are mostly curative for localized disease, but do not completely preclude recurrence and metastization. Thus, it is imperative to develop new therapeutic strategies based on RCC biological properties. Presently, metabolic reprograming and epigenetic alterations are recognized cancer hallmarks and their interactions are still in its infancy concerning RCC. In this review, we explore RCC biology, highlighting genetic and epigenetic alterations that contribute to metabolic deregulation of tumor cells, including high glycolytic phenotype (Warburg effect). Moreover, we critically discuss available data concerning epigenetic enzymes’ regulation by aberrant metabolite accumulation and their consequences in RCC emergence and progression. Finally, we emphasize the clinical relevance of uncovering novel therapeutic targets based on epigenetic reprograming by metabolic features to improve treatment and survival of RCC patients.https://www.mdpi.com/2073-4425/10/4/264renal cell carcinomametabolic reprogramingWarburg effectepigenetic alterations |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Lameirinhas Vera Miranda-Gonçalves Rui Henrique Carmen Jerónimo |
spellingShingle |
Ana Lameirinhas Vera Miranda-Gonçalves Rui Henrique Carmen Jerónimo The Complex Interplay between Metabolic Reprogramming and Epigenetic Alterations in Renal Cell Carcinoma Genes renal cell carcinoma metabolic reprograming Warburg effect epigenetic alterations |
author_facet |
Ana Lameirinhas Vera Miranda-Gonçalves Rui Henrique Carmen Jerónimo |
author_sort |
Ana Lameirinhas |
title |
The Complex Interplay between Metabolic Reprogramming and Epigenetic Alterations in Renal Cell Carcinoma |
title_short |
The Complex Interplay between Metabolic Reprogramming and Epigenetic Alterations in Renal Cell Carcinoma |
title_full |
The Complex Interplay between Metabolic Reprogramming and Epigenetic Alterations in Renal Cell Carcinoma |
title_fullStr |
The Complex Interplay between Metabolic Reprogramming and Epigenetic Alterations in Renal Cell Carcinoma |
title_full_unstemmed |
The Complex Interplay between Metabolic Reprogramming and Epigenetic Alterations in Renal Cell Carcinoma |
title_sort |
complex interplay between metabolic reprogramming and epigenetic alterations in renal cell carcinoma |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2019-04-01 |
description |
Renal cell carcinoma (RCC) is the most common malignancy affecting the kidney. Current therapies are mostly curative for localized disease, but do not completely preclude recurrence and metastization. Thus, it is imperative to develop new therapeutic strategies based on RCC biological properties. Presently, metabolic reprograming and epigenetic alterations are recognized cancer hallmarks and their interactions are still in its infancy concerning RCC. In this review, we explore RCC biology, highlighting genetic and epigenetic alterations that contribute to metabolic deregulation of tumor cells, including high glycolytic phenotype (Warburg effect). Moreover, we critically discuss available data concerning epigenetic enzymes’ regulation by aberrant metabolite accumulation and their consequences in RCC emergence and progression. Finally, we emphasize the clinical relevance of uncovering novel therapeutic targets based on epigenetic reprograming by metabolic features to improve treatment and survival of RCC patients. |
topic |
renal cell carcinoma metabolic reprograming Warburg effect epigenetic alterations |
url |
https://www.mdpi.com/2073-4425/10/4/264 |
work_keys_str_mv |
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