A Case of Conjunctival Amyloidosis with Repeated Subconjunctival Hemorrhage
Conjunctival amyloidosis is a very rare disease, and its presence may be a sign of systemic amyloidosis. We present our ocular and systemic findings in a patient with conjunctival amyloidosis. A 43-year-old man had repeated subconjunctival hemorrhages (SCHs) for two years and was referred to the Chi...
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doaj-61b8de4cfbd7490894a3aca0d7e3fdc42020-11-24T22:54:13ZengHindawi LimitedCase Reports in Ophthalmological Medicine2090-67222090-67302017-01-01201710.1155/2017/54230275423027A Case of Conjunctival Amyloidosis with Repeated Subconjunctival HemorrhageTakaaki Ando0Toshiyuki Oshitari1Mamiko Saito2Ayako Tawada3Takayuki Baba4Jiro Yotsukura5Shuichi Yamamoto6Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanDepartment of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JapanConjunctival amyloidosis is a very rare disease, and its presence may be a sign of systemic amyloidosis. We present our ocular and systemic findings in a patient with conjunctival amyloidosis. A 43-year-old man had repeated subconjunctival hemorrhages (SCHs) for two years and was referred to the Chiba University Hospital. He had comprehensive ophthalmological and systemic examinations to determine the cause of the SCHs. His visual acuities were 1.2 OU, and the intraocular pressures were 13-14 mmHg OU. Magnetic resonance imaging was normal. Initially, the SCH was the only abnormality. After 3 months, the SCH had partially cleared, and a pink mass was detected in the superior area of the subconjunctiva. Partial biopsy and histopathological examinations showed a greenish birefringence and dichroism under polarized light illumination. The birefringence was located in amyloid fibers. Immunofixation electrophoresis detected λ-light chain abnormality in the ocular biopsy specimen but systemic examinations did not find any lesions. Multiple myeloma was ruled out, and the patient is being followed closely to detect any early signs of systemic amyloidosis. Because repeated SCHs might be initial signs of systemic amyloidosis, patients with conjunctival amyloidosis should be comprehensively examined for systemic amyloidosis because of its poor life prognosis.http://dx.doi.org/10.1155/2017/5423027 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takaaki Ando Toshiyuki Oshitari Mamiko Saito Ayako Tawada Takayuki Baba Jiro Yotsukura Shuichi Yamamoto |
spellingShingle |
Takaaki Ando Toshiyuki Oshitari Mamiko Saito Ayako Tawada Takayuki Baba Jiro Yotsukura Shuichi Yamamoto A Case of Conjunctival Amyloidosis with Repeated Subconjunctival Hemorrhage Case Reports in Ophthalmological Medicine |
author_facet |
Takaaki Ando Toshiyuki Oshitari Mamiko Saito Ayako Tawada Takayuki Baba Jiro Yotsukura Shuichi Yamamoto |
author_sort |
Takaaki Ando |
title |
A Case of Conjunctival Amyloidosis with Repeated Subconjunctival Hemorrhage |
title_short |
A Case of Conjunctival Amyloidosis with Repeated Subconjunctival Hemorrhage |
title_full |
A Case of Conjunctival Amyloidosis with Repeated Subconjunctival Hemorrhage |
title_fullStr |
A Case of Conjunctival Amyloidosis with Repeated Subconjunctival Hemorrhage |
title_full_unstemmed |
A Case of Conjunctival Amyloidosis with Repeated Subconjunctival Hemorrhage |
title_sort |
case of conjunctival amyloidosis with repeated subconjunctival hemorrhage |
publisher |
Hindawi Limited |
series |
Case Reports in Ophthalmological Medicine |
issn |
2090-6722 2090-6730 |
publishDate |
2017-01-01 |
description |
Conjunctival amyloidosis is a very rare disease, and its presence may be a sign of systemic amyloidosis. We present our ocular and systemic findings in a patient with conjunctival amyloidosis. A 43-year-old man had repeated subconjunctival hemorrhages (SCHs) for two years and was referred to the Chiba University Hospital. He had comprehensive ophthalmological and systemic examinations to determine the cause of the SCHs. His visual acuities were 1.2 OU, and the intraocular pressures were 13-14 mmHg OU. Magnetic resonance imaging was normal. Initially, the SCH was the only abnormality. After 3 months, the SCH had partially cleared, and a pink mass was detected in the superior area of the subconjunctiva. Partial biopsy and histopathological examinations showed a greenish birefringence and dichroism under polarized light illumination. The birefringence was located in amyloid fibers. Immunofixation electrophoresis detected λ-light chain abnormality in the ocular biopsy specimen but systemic examinations did not find any lesions. Multiple myeloma was ruled out, and the patient is being followed closely to detect any early signs of systemic amyloidosis. Because repeated SCHs might be initial signs of systemic amyloidosis, patients with conjunctival amyloidosis should be comprehensively examined for systemic amyloidosis because of its poor life prognosis. |
url |
http://dx.doi.org/10.1155/2017/5423027 |
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