Role of FGF10/FGFR2b Signaling in Mouse Digestive Tract Development, Repair and Regeneration Following Injury
During embryonic development, the rudimentary digestive tract is initially a tube-like structure. It is composed of epithelial cells surrounded by mesenchymal cells. Reciprocal epithelial–mesenchymal interactions progressively subdivide this primitive tube into distinct functional regions: the tongu...
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doaj-61bcd57e2c004b06a9ca2dda12ec5c4c2020-11-25T02:10:06ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2019-12-01710.3389/fcell.2019.00326504742Role of FGF10/FGFR2b Signaling in Mouse Digestive Tract Development, Repair and Regeneration Following InjuryYu-Qing Lv0Yu-Qing Lv1Jin Wu2Xiao-Kun Li3Xiao-Kun Li4Jin-San Zhang5Jin-San Zhang6Saverio Bellusci7Saverio Bellusci8Saverio Bellusci9Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaInstitute of Life Sciences, Wenzhou University, Wenzhou, ChinaInstitute of Life Sciences, Wenzhou University, Wenzhou, ChinaKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaInstitute of Life Sciences, Wenzhou University, Wenzhou, ChinaKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaInstitute of Life Sciences, Wenzhou University, Wenzhou, ChinaKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaInstitute of Life Sciences, Wenzhou University, Wenzhou, ChinaDepartment of Internal Medicine II, Cardio-Pulmonary Institute, University of Giessen and Marburg Lung Center, Giessen, GermanyDuring embryonic development, the rudimentary digestive tract is initially a tube-like structure. It is composed of epithelial cells surrounded by mesenchymal cells. Reciprocal epithelial–mesenchymal interactions progressively subdivide this primitive tube into distinct functional regions: the tongue, the pharynx, the esophagus, the stomach, the duodenum, the small intestine, the cecum, the large intestine, the colon, and the anus as well as the pancreas and the liver. Fibroblast growth factors (Fgfs) constitute a family of conserved small proteins playing crucial roles during organogenesis, homeostasis, and repair after injury. Among them, fibroblast growth factor 10 (Fgf10) has been reported to orchestrate epithelial–mesenchymal interactions during digestive tract development. In mice, loss of function of Fgf10 as well as its receptor fibroblast growth factor receptor 2b (Fgfr2b) lead to defective taste papillae in the tongue, underdeveloped and defective differentiation of the stomach, duodenal, cecal, and colonic atresias, anorectal malformation, as well as underdeveloped pancreas and liver. Fgf signaling through Fgfr2b receptor is also critical for the repair process after gut injury. In the adult mice, a malabsorption disorder called small bowel syndrome is triggered after massive small bowel resection (SBR). In wild-type mice, SBR leads to a regenerative process called gut adaptation characterized by an increase in the diameter of the remaining small intestine as well as by the presence of deeper crypts and longer villi, altogether leading to increased intestinal surface. Intestinal stem cells are key for this regeneration process. Induction of Fgf10 expression in the Paneth cells located in the crypt following SBR suggests a critical role for this growth factor in the process of gut adaptation.https://www.frontiersin.org/article/10.3389/fcell.2019.00326/fullFgf10digestive tract organogenesisstem cellsregenerationsmall bowel resectionrepair |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu-Qing Lv Yu-Qing Lv Jin Wu Xiao-Kun Li Xiao-Kun Li Jin-San Zhang Jin-San Zhang Saverio Bellusci Saverio Bellusci Saverio Bellusci |
spellingShingle |
Yu-Qing Lv Yu-Qing Lv Jin Wu Xiao-Kun Li Xiao-Kun Li Jin-San Zhang Jin-San Zhang Saverio Bellusci Saverio Bellusci Saverio Bellusci Role of FGF10/FGFR2b Signaling in Mouse Digestive Tract Development, Repair and Regeneration Following Injury Frontiers in Cell and Developmental Biology Fgf10 digestive tract organogenesis stem cells regeneration small bowel resection repair |
author_facet |
Yu-Qing Lv Yu-Qing Lv Jin Wu Xiao-Kun Li Xiao-Kun Li Jin-San Zhang Jin-San Zhang Saverio Bellusci Saverio Bellusci Saverio Bellusci |
author_sort |
Yu-Qing Lv |
title |
Role of FGF10/FGFR2b Signaling in Mouse Digestive Tract Development, Repair and Regeneration Following Injury |
title_short |
Role of FGF10/FGFR2b Signaling in Mouse Digestive Tract Development, Repair and Regeneration Following Injury |
title_full |
Role of FGF10/FGFR2b Signaling in Mouse Digestive Tract Development, Repair and Regeneration Following Injury |
title_fullStr |
Role of FGF10/FGFR2b Signaling in Mouse Digestive Tract Development, Repair and Regeneration Following Injury |
title_full_unstemmed |
Role of FGF10/FGFR2b Signaling in Mouse Digestive Tract Development, Repair and Regeneration Following Injury |
title_sort |
role of fgf10/fgfr2b signaling in mouse digestive tract development, repair and regeneration following injury |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2019-12-01 |
description |
During embryonic development, the rudimentary digestive tract is initially a tube-like structure. It is composed of epithelial cells surrounded by mesenchymal cells. Reciprocal epithelial–mesenchymal interactions progressively subdivide this primitive tube into distinct functional regions: the tongue, the pharynx, the esophagus, the stomach, the duodenum, the small intestine, the cecum, the large intestine, the colon, and the anus as well as the pancreas and the liver. Fibroblast growth factors (Fgfs) constitute a family of conserved small proteins playing crucial roles during organogenesis, homeostasis, and repair after injury. Among them, fibroblast growth factor 10 (Fgf10) has been reported to orchestrate epithelial–mesenchymal interactions during digestive tract development. In mice, loss of function of Fgf10 as well as its receptor fibroblast growth factor receptor 2b (Fgfr2b) lead to defective taste papillae in the tongue, underdeveloped and defective differentiation of the stomach, duodenal, cecal, and colonic atresias, anorectal malformation, as well as underdeveloped pancreas and liver. Fgf signaling through Fgfr2b receptor is also critical for the repair process after gut injury. In the adult mice, a malabsorption disorder called small bowel syndrome is triggered after massive small bowel resection (SBR). In wild-type mice, SBR leads to a regenerative process called gut adaptation characterized by an increase in the diameter of the remaining small intestine as well as by the presence of deeper crypts and longer villi, altogether leading to increased intestinal surface. Intestinal stem cells are key for this regeneration process. Induction of Fgf10 expression in the Paneth cells located in the crypt following SBR suggests a critical role for this growth factor in the process of gut adaptation. |
topic |
Fgf10 digestive tract organogenesis stem cells regeneration small bowel resection repair |
url |
https://www.frontiersin.org/article/10.3389/fcell.2019.00326/full |
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