Neuroimaging advances in Parkinson's disease with freezing of gait: A systematic review
Freezing of gait (FOG) is a paroxysmal gait disorder that often occurs at advanced stages of Parkinson's disease (PD). FOG consists of abrupt walking interruption and severe difficulty in locomotion with an increased risk of falling. Pathophysiological mechanisms underpinning FOG in PD are stil...
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doaj-61d0070c55304f26949004250c937cca2020-11-25T00:43:24ZengElsevierNeuroImage: Clinical2213-15822019-01-0124Neuroimaging advances in Parkinson's disease with freezing of gait: A systematic reviewKomal Bharti0Antonio Suppa1Silvia Tommasin2Alessandro Zampogna3Sara Pietracupa4Alfredo Berardelli5Patrizia Pantano6Department of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy; IRCCS Neuromed, Pozzilli (IS), ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, ItalyIRCCS Neuromed, Pozzilli (IS), ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy; IRCCS Neuromed, Pozzilli (IS), ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy; IRCCS Neuromed, Pozzilli (IS), Italy; Corresponding author at: Department of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy.Freezing of gait (FOG) is a paroxysmal gait disorder that often occurs at advanced stages of Parkinson's disease (PD). FOG consists of abrupt walking interruption and severe difficulty in locomotion with an increased risk of falling. Pathophysiological mechanisms underpinning FOG in PD are still unclear. However, advanced MRI and nuclear medicine studies have gained relevant insights into the pathophysiology of FOG in PD. Neuroimaging studies have demonstrated structural and functional abnormalities in a number of cortical and subcortical brain regions in PD patients with FOG. In this paper, we systematically review existing neuroimaging literature on the structural and functional brain changes described in PD patients with FOG, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We evaluate previous studies using various MRI techniques to estimate grey matter loss and white matter degeneration. Moreover, we review functional brain changes by examining functional MRI and nuclear medicine imaging studies. The current review provides up-to-date knowledge in this field and summarizes the possible mechanisms responsible for FOG in PD. Keywords: Parkinson's disease, Freezing of gait, MRI, PET, SPECThttp://www.sciencedirect.com/science/article/pii/S2213158219304061 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Komal Bharti Antonio Suppa Silvia Tommasin Alessandro Zampogna Sara Pietracupa Alfredo Berardelli Patrizia Pantano |
spellingShingle |
Komal Bharti Antonio Suppa Silvia Tommasin Alessandro Zampogna Sara Pietracupa Alfredo Berardelli Patrizia Pantano Neuroimaging advances in Parkinson's disease with freezing of gait: A systematic review NeuroImage: Clinical |
author_facet |
Komal Bharti Antonio Suppa Silvia Tommasin Alessandro Zampogna Sara Pietracupa Alfredo Berardelli Patrizia Pantano |
author_sort |
Komal Bharti |
title |
Neuroimaging advances in Parkinson's disease with freezing of gait: A systematic review |
title_short |
Neuroimaging advances in Parkinson's disease with freezing of gait: A systematic review |
title_full |
Neuroimaging advances in Parkinson's disease with freezing of gait: A systematic review |
title_fullStr |
Neuroimaging advances in Parkinson's disease with freezing of gait: A systematic review |
title_full_unstemmed |
Neuroimaging advances in Parkinson's disease with freezing of gait: A systematic review |
title_sort |
neuroimaging advances in parkinson's disease with freezing of gait: a systematic review |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2019-01-01 |
description |
Freezing of gait (FOG) is a paroxysmal gait disorder that often occurs at advanced stages of Parkinson's disease (PD). FOG consists of abrupt walking interruption and severe difficulty in locomotion with an increased risk of falling. Pathophysiological mechanisms underpinning FOG in PD are still unclear. However, advanced MRI and nuclear medicine studies have gained relevant insights into the pathophysiology of FOG in PD. Neuroimaging studies have demonstrated structural and functional abnormalities in a number of cortical and subcortical brain regions in PD patients with FOG. In this paper, we systematically review existing neuroimaging literature on the structural and functional brain changes described in PD patients with FOG, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We evaluate previous studies using various MRI techniques to estimate grey matter loss and white matter degeneration. Moreover, we review functional brain changes by examining functional MRI and nuclear medicine imaging studies. The current review provides up-to-date knowledge in this field and summarizes the possible mechanisms responsible for FOG in PD. Keywords: Parkinson's disease, Freezing of gait, MRI, PET, SPECT |
url |
http://www.sciencedirect.com/science/article/pii/S2213158219304061 |
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