Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions
2-Aryl-6-cyano-7-methyl-5-indolizinones were successfully converted into 2-aryl-5-chloro-6-cyano-7-methylindolizines. The obtained 5-chloroindolizines readily underwent nucleophilic substitution at position 5 leading in high yields to novel 5-functionalised indolizines.
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Beilstein-Institut
2005-10-01
|
| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/1860-5397-1-9 |
| id |
doaj-61d447511af3433f99844370a4916915 |
|---|---|
| record_format |
Article |
| spelling |
doaj-61d447511af3433f99844370a49169152021-04-02T07:13:29ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972005-10-0111910.1186/1860-5397-1-91860-5397-1-9Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactionsEugene V. Babaev0Natalya I. Vasilevich1Anna S. Ivushkina2Department of Chemistry, Moscow State University, 119992, Moscow, RussiaDepartment of Chemistry, Moscow State University, 119992, Moscow, RussiaDepartment of Chemistry, Moscow State University, 119992, Moscow, Russia2-Aryl-6-cyano-7-methyl-5-indolizinones were successfully converted into 2-aryl-5-chloro-6-cyano-7-methylindolizines. The obtained 5-chloroindolizines readily underwent nucleophilic substitution at position 5 leading in high yields to novel 5-functionalised indolizines.https://doi.org/10.1186/1860-5397-1-95-chloroindolizine5-substituted indolizines5-indolizinonenucleophilic substitution |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Eugene V. Babaev Natalya I. Vasilevich Anna S. Ivushkina |
| spellingShingle |
Eugene V. Babaev Natalya I. Vasilevich Anna S. Ivushkina Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions Beilstein Journal of Organic Chemistry 5-chloroindolizine 5-substituted indolizines 5-indolizinone nucleophilic substitution |
| author_facet |
Eugene V. Babaev Natalya I. Vasilevich Anna S. Ivushkina |
| author_sort |
Eugene V. Babaev |
| title |
Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions |
| title_short |
Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions |
| title_full |
Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions |
| title_fullStr |
Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions |
| title_full_unstemmed |
Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions |
| title_sort |
efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions |
| publisher |
Beilstein-Institut |
| series |
Beilstein Journal of Organic Chemistry |
| issn |
1860-5397 |
| publishDate |
2005-10-01 |
| description |
2-Aryl-6-cyano-7-methyl-5-indolizinones were successfully converted into 2-aryl-5-chloro-6-cyano-7-methylindolizines. The obtained 5-chloroindolizines readily underwent nucleophilic substitution at position 5 leading in high yields to novel 5-functionalised indolizines. |
| topic |
5-chloroindolizine 5-substituted indolizines 5-indolizinone nucleophilic substitution |
| url |
https://doi.org/10.1186/1860-5397-1-9 |
| work_keys_str_mv |
AT eugenevbabaev efficientsynthesisof5substituted2aryl6cyanoindolizinesvianucleophilicsubstitutionreactions AT natalyaivasilevich efficientsynthesisof5substituted2aryl6cyanoindolizinesvianucleophilicsubstitutionreactions AT annasivushkina efficientsynthesisof5substituted2aryl6cyanoindolizinesvianucleophilicsubstitutionreactions |
| _version_ |
1724171333405769728 |