Hemolytic and antimalarial effects of tight-binding glyoxalase 1 inhibitors on the host-parasite unit of erythrocytes infected with Plasmodium falciparum
Glyoxalases prevent the formation of advanced glycation end products by converting glycolysis-derived methylglyoxal to d-lactate with the help of glutathione. Vander Jagt and colleagues previously showed that erythrocytes release about thirty times more d-lactate after infection with the human malar...
Main Authors: | Cletus A. Wezena, Miriam Urscher, Robert Vince, Swati S. More, Marcel Deponte |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2016-08-01
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Series: | Redox Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231716300179 |
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