A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum

A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum

Multi-target strategies are directed toward targets that are unrelated (or distantly related) and can create opportunities to address different pathologies. The antidermatophytic activities of nine natural skin lighteners: α-bisabolol, kojic acid, β-arbutin, azelaic acid, hydroquinone, nicotinamide,...

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Main Authors: Carlo Romagnoli, Anna Baldisserotto, Gemma Malisardi, Chiara B. Vicentini, Donatella Mares, Elisa Andreotti, Silvia Vertuani, Stefano Manfredini
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Molecules
Subjects:
antifungal activity
dermatophytes
M. gypseum
α-bisabolol
TEM
skin lightener
Online Access:http://www.mdpi.com/1420-3049/20/7/11765
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spelling doaj-61e5ca133cde4c77946fe47cb135b6122020-11-24T23:49:31ZengMDPI AGMolecules1420-30492015-06-01207117651177610.3390/molecules200711765molecules200711765A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseumCarlo Romagnoli0Anna Baldisserotto1Gemma Malisardi2Chiara B. Vicentini3Donatella Mares4Elisa Andreotti5Silvia Vertuani6Stefano Manfredini7Department of Life Sciences, University of Modena and Reggio Emilia, viale Caduti in Guerra 127, 41121 Modena, ItalyDepartment of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, ItalyDepartment of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, ItalyDepartment of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, ItalyDepartment of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, ItalyDepartment of Life Sciences, University of Modena and Reggio Emilia, viale Caduti in Guerra 127, 41121 Modena, ItalyDepartment of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, ItalyDepartment of Life Sciences and Biotechnology, Master Course in Cosmetic Science and Technology, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, ItalyMulti-target strategies are directed toward targets that are unrelated (or distantly related) and can create opportunities to address different pathologies. The antidermatophytic activities of nine natural skin lighteners: α-bisabolol, kojic acid, β-arbutin, azelaic acid, hydroquinone, nicotinamide, glycine, glutathione and ascorbyl tetraisopalmitate, were evaluated, in comparison with the known antifungal drug fluconazole, on nine dermatophytes responsible for the most common dermatomycoses: Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Nannizzia cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Arthroderma gypseum, Trichophyton rubrum and Trichophyton tonsurans. α-Bisabolol showed the best antifungal activity against all fungi and in particular; against M. gypseum. Further investigations were conducted on this fungus to evaluate the inhibition of spore germination and morphological changes induced by α-bisabolol by TEM.http://www.mdpi.com/1420-3049/20/7/11765antifungal activitydermatophytesM. gypseumα-bisabololTEMskin lightener
collection DOAJ
language English
format Article
sources DOAJ
author Carlo Romagnoli
Anna Baldisserotto
Gemma Malisardi
Chiara B. Vicentini
Donatella Mares
Elisa Andreotti
Silvia Vertuani
Stefano Manfredini
spellingShingle Carlo Romagnoli
Anna Baldisserotto
Gemma Malisardi
Chiara B. Vicentini
Donatella Mares
Elisa Andreotti
Silvia Vertuani
Stefano Manfredini
A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum
Molecules
antifungal activity
dermatophytes
M. gypseum
α-bisabolol
TEM
skin lightener
author_facet Carlo Romagnoli
Anna Baldisserotto
Gemma Malisardi
Chiara B. Vicentini
Donatella Mares
Elisa Andreotti
Silvia Vertuani
Stefano Manfredini
author_sort Carlo Romagnoli
title A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum
title_short A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum
title_full A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum
title_fullStr A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum
title_full_unstemmed A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum
title_sort multi-target approach toward the development of novel candidates for antidermatophytic activity: ultrastructural evidence on α-bisabolol-treated microsporum gypseum
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2015-06-01
description Multi-target strategies are directed toward targets that are unrelated (or distantly related) and can create opportunities to address different pathologies. The antidermatophytic activities of nine natural skin lighteners: α-bisabolol, kojic acid, β-arbutin, azelaic acid, hydroquinone, nicotinamide, glycine, glutathione and ascorbyl tetraisopalmitate, were evaluated, in comparison with the known antifungal drug fluconazole, on nine dermatophytes responsible for the most common dermatomycoses: Microsporum gypseum, Microsporum canis, Trichophyton violaceum, Nannizzia cajetani, Trichophyton mentagrophytes, Epidermophyton floccosum, Arthroderma gypseum, Trichophyton rubrum and Trichophyton tonsurans. α-Bisabolol showed the best antifungal activity against all fungi and in particular; against M. gypseum. Further investigations were conducted on this fungus to evaluate the inhibition of spore germination and morphological changes induced by α-bisabolol by TEM.
topic antifungal activity
dermatophytes
M. gypseum
α-bisabolol
TEM
skin lightener
url http://www.mdpi.com/1420-3049/20/7/11765
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