Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy?

Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy?

Fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) are the two main cellular components of the synovium. It has been widely reported that FLS and MLS play essential roles in the joint pathology of rheumatoid arthritis (RA). Although various studies have analyzed both human and...

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Bibliographic Details
Main Authors: Jiajie Tu, Wenming Hong, Pengying Zhang, Xinming Wang, Heinrich Körner, Wei Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
fibroblast-like synoviocytes
macrophage-like synoviocytes
rheumatoid arthritis
synovium
ontology
treatment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01467/full

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