Fetal Exposure to Chinese Famine Increases Obesity Risk in Adulthood
Fetal exposure to famine may have long-term consequences in adulthood. The purpose of the present study was to explore the association between famine exposure in fetal life (Chinese famine in 1959–1961) and obesity risk in adulthood. A total of 8054 subjects (3422 male, 4632 female) were recruited f...
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doaj-6220ef5009b74d109a56d8717f263d0a2020-11-25T03:22:53ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012020-05-01173649364910.3390/ijerph17103649Fetal Exposure to Chinese Famine Increases Obesity Risk in AdulthoodChao Song0Meng Wang1Zheng Chen2Yecheng Yao3Ganyu Feng4Yanning Ma5Jing Fan6Ailing Liu7National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing 100050, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing 100050, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing 100050, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing 100050, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing 100050, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing 100050, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing 100050, ChinaNational Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing 100050, ChinaFetal exposure to famine may have long-term consequences in adulthood. The purpose of the present study was to explore the association between famine exposure in fetal life (Chinese famine in 1959–1961) and obesity risk in adulthood. A total of 8054 subjects (3422 male, 4632 female) were recruited from the cross-sectional 2010–2012 China National Nutrition and Health Survey (CNNHS). The subjects born in 1960 and 1961 were selected as the exposed group, while the subjects born in 1963 were selected as the unexposed group. Multiple linear or logistic regression was performed to examine the association between fetal exposure to famine and risk of obesity (body mass index (BMI), waist circumference (WC), obesity, central obesity) adjusting for gender, education level, economic status, physical exercise, sedentary time, smoking, drinking, the intake of livestock and poultry and the intake of cereal and beans. Compared with the unexposed group, WC increased by 0.52 cm after adjusting the covariates <i>(p =</i> 0.021) and females in the exposed group had a significantly higher prevalence of central obesity with an odds ratio (OR) of 1.15 (1.01,1.31) after adjusting the confounders (<i>p</i> = 0.030). WC increased by 0.71 cm, 1.21 cm after adjusting the covariates compared with the unexposed group among the total subjects and the female subjects in urban areas (<i>p</i> = 0.021, <i>p</i> = 0.001). The female subjects had a significantly higher prevalence of obesity and central obesity, with ORs of 1.34 (1.04,1.71) (<i>p</i> = 0.022), 1.28 (1.07,1.53) (<i>p</i> = 0.008) respectively. Our results suggest that fetal exposure to the Chinese famine increased obesity risk in adulthood, and the association was stronger in female and urban subjects.https://www.mdpi.com/1660-4601/17/10/3649famineobesityfetal life |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chao Song Meng Wang Zheng Chen Yecheng Yao Ganyu Feng Yanning Ma Jing Fan Ailing Liu |
spellingShingle |
Chao Song Meng Wang Zheng Chen Yecheng Yao Ganyu Feng Yanning Ma Jing Fan Ailing Liu Fetal Exposure to Chinese Famine Increases Obesity Risk in Adulthood International Journal of Environmental Research and Public Health famine obesity fetal life |
author_facet |
Chao Song Meng Wang Zheng Chen Yecheng Yao Ganyu Feng Yanning Ma Jing Fan Ailing Liu |
author_sort |
Chao Song |
title |
Fetal Exposure to Chinese Famine Increases Obesity Risk in Adulthood |
title_short |
Fetal Exposure to Chinese Famine Increases Obesity Risk in Adulthood |
title_full |
Fetal Exposure to Chinese Famine Increases Obesity Risk in Adulthood |
title_fullStr |
Fetal Exposure to Chinese Famine Increases Obesity Risk in Adulthood |
title_full_unstemmed |
Fetal Exposure to Chinese Famine Increases Obesity Risk in Adulthood |
title_sort |
fetal exposure to chinese famine increases obesity risk in adulthood |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2020-05-01 |
description |
Fetal exposure to famine may have long-term consequences in adulthood. The purpose of the present study was to explore the association between famine exposure in fetal life (Chinese famine in 1959–1961) and obesity risk in adulthood. A total of 8054 subjects (3422 male, 4632 female) were recruited from the cross-sectional 2010–2012 China National Nutrition and Health Survey (CNNHS). The subjects born in 1960 and 1961 were selected as the exposed group, while the subjects born in 1963 were selected as the unexposed group. Multiple linear or logistic regression was performed to examine the association between fetal exposure to famine and risk of obesity (body mass index (BMI), waist circumference (WC), obesity, central obesity) adjusting for gender, education level, economic status, physical exercise, sedentary time, smoking, drinking, the intake of livestock and poultry and the intake of cereal and beans. Compared with the unexposed group, WC increased by 0.52 cm after adjusting the covariates <i>(p =</i> 0.021) and females in the exposed group had a significantly higher prevalence of central obesity with an odds ratio (OR) of 1.15 (1.01,1.31) after adjusting the confounders (<i>p</i> = 0.030). WC increased by 0.71 cm, 1.21 cm after adjusting the covariates compared with the unexposed group among the total subjects and the female subjects in urban areas (<i>p</i> = 0.021, <i>p</i> = 0.001). The female subjects had a significantly higher prevalence of obesity and central obesity, with ORs of 1.34 (1.04,1.71) (<i>p</i> = 0.022), 1.28 (1.07,1.53) (<i>p</i> = 0.008) respectively. Our results suggest that fetal exposure to the Chinese famine increased obesity risk in adulthood, and the association was stronger in female and urban subjects. |
topic |
famine obesity fetal life |
url |
https://www.mdpi.com/1660-4601/17/10/3649 |
work_keys_str_mv |
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