Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral Immunotherapy

Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral Immunotherapy

Sarcoma is comprised of a heterogeneous group of tumors originating from the mesenchyme. Sarcoma is also the first tumor that responded to immunotherapeutic agents often termed as “Coley’s toxins.” However, immunotherapy is yet to establish its presence in sarcomas. Complex interactions between tumo...

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Main Authors: Shailaja Raj, Lance D. Miller, Pierre L. Triozzi
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Sarcoma
Online Access:http://dx.doi.org/10.1155/2018/9305294
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spelling doaj-6226397c4ecb409e86f8911d00494f2f2020-11-24T23:23:49ZengHindawi LimitedSarcoma1357-714X1369-16432018-01-01201810.1155/2018/93052949305294Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral ImmunotherapyShailaja Raj0Lance D. Miller1Pierre L. Triozzi2Wake Forest School of Medicine, Winston-Salem, NC, USAWake Forest School of Medicine, Winston-Salem, NC, USAWake Forest School of Medicine, Winston-Salem, NC, USASarcoma is comprised of a heterogeneous group of tumors originating from the mesenchyme. Sarcoma is also the first tumor that responded to immunotherapeutic agents often termed as “Coley’s toxins.” However, immunotherapy is yet to establish its presence in sarcomas. Complex interactions between tumor and immune cells in the tumor microenvironment play a crucial role in response to immunotherapy. There is a dynamic equilibrium created by the immune cells infiltrating the tumor, and this forms the basis of tumor evasion. Manipulating the intratumoral microenvironment will help overcome tumor evasion.http://dx.doi.org/10.1155/2018/9305294
collection DOAJ
language English
format Article
sources DOAJ
author Shailaja Raj
Lance D. Miller
Pierre L. Triozzi
spellingShingle Shailaja Raj
Lance D. Miller
Pierre L. Triozzi
Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral Immunotherapy
Sarcoma
author_facet Shailaja Raj
Lance D. Miller
Pierre L. Triozzi
author_sort Shailaja Raj
title Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral Immunotherapy
title_short Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral Immunotherapy
title_full Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral Immunotherapy
title_fullStr Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral Immunotherapy
title_full_unstemmed Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral Immunotherapy
title_sort addressing the adult soft tissue sarcoma microenvironment with intratumoral immunotherapy
publisher Hindawi Limited
series Sarcoma
issn 1357-714X
1369-1643
publishDate 2018-01-01
description Sarcoma is comprised of a heterogeneous group of tumors originating from the mesenchyme. Sarcoma is also the first tumor that responded to immunotherapeutic agents often termed as “Coley’s toxins.” However, immunotherapy is yet to establish its presence in sarcomas. Complex interactions between tumor and immune cells in the tumor microenvironment play a crucial role in response to immunotherapy. There is a dynamic equilibrium created by the immune cells infiltrating the tumor, and this forms the basis of tumor evasion. Manipulating the intratumoral microenvironment will help overcome tumor evasion.
url http://dx.doi.org/10.1155/2018/9305294
work_keys_str_mv AT shailajaraj addressingtheadultsofttissuesarcomamicroenvironmentwithintratumoralimmunotherapy
AT lancedmiller addressingtheadultsofttissuesarcomamicroenvironmentwithintratumoralimmunotherapy
AT pierreltriozzi addressingtheadultsofttissuesarcomamicroenvironmentwithintratumoralimmunotherapy
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