Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1

Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1

Abstract Chondrosarcoma (CHS) is the second most common bone malignancy with limited therapeutic approaches. Our previous study has found that Yes associated protein 1 (YAP1) is downregulated in CHS cells treated with bromodomain and extraterminal domain (BET) inhibitor JQ1. However, the precise rol...

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Bibliographic Details
Main Authors: Huan-Tian Zhang, Tao Gui, Ri-Xu Liu, Kui-Leung Tong, Chong-Jie Wu, Zhenyan Li, Xun Huang, Qiu-Tong Xu, Jie Yang, Wang Tang, Yuan Sang, Wanting Liu, Ning Liu, Ryan D. Ross, Qing-Yu He, Zhen-Gang Zha
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03416-1

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