Effect of liraglutide on blood pressure: a meta-analysis of liraglutide randomized controlled trials
Abstract Background Several clinical trials have studied the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on glycometabolism and cardiovascular risk factors since they were identified. Because of their cardiovascular benefits and efficacy in lowering glucose, GLP-1RAs are becoming...
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doaj-62544b8c54bd4c8880c0db4252ade8912020-11-25T01:22:54ZengBMCBMC Endocrine Disorders1472-68232019-01-0119111410.1186/s12902-018-0332-5Effect of liraglutide on blood pressure: a meta-analysis of liraglutide randomized controlled trialsXu Zhao0Kun Huang1Meijie Zheng2Junting Duan3Civil Aviation General Hospital, Peking UniversityCivil Aviation General Hospital, Peking UniversityCivil Aviation General Hospital, Peking UniversityCivil Aviation General Hospital, Peking UniversityAbstract Background Several clinical trials have studied the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on glycometabolism and cardiovascular risk factors since they were identified. Because of their cardiovascular benefits and efficacy in lowering glucose, GLP-1RAs are becoming increasingly important in clinical therapy for patients with or without pathoglycaemia. The aim of this study was to assess the effect of the GLP-1RA liraglutide on blood pressure based on randomised controlled trials (RCTs). Methods We searched PubMed for RCTs published from 2009 to 2018 comparing the effect of liraglutide on blood pressure with that of placebo in individuals with or without pathoglycaemia. RCTs in humans that included data describing blood pressure changes from baseline to the end of the trial were selected for inclusion in the meta-analysis. Results A total of 18 RCTs that enrolled 7616 individuals in the liraglutide group and 6046 individuals in the control group were included in this meta-analysis. Compared with placebo, liraglutide reduced systolic blood pressure (SBP) by 3.18 mmHg (95% CI -4.32, − 2.05), P < 0.00001, but had no significant effect on diastolic blood pressure (DBP). Subgroup analysis showed that the degree of reduction in SBP was associated with the dose of liraglutide but that significance disappeared when the intervention lasted over 1 year. Liraglutide 3.0 mg/d significantly reduced DBP by 1.46 mmHg (95% CI -2.61, 0.32), P = 0.01, but liraglutide 1.8 mg/d slightly increased DBP by 0.47 mmHg (95% CI 0.11, 0.83), P = 0.01, compared with placebo. Conclusions This meta-analysis demonstrated that liraglutide significantly reduced SBP in individuals with or without pathoglycaemia compared with placebo, but the difference was no longer significant when the intervention lasted over 1 year. Moreover, the effect of liraglutide on blood pressure is associated with the dose. This finding may provide additional evidence for cardiovascular protection.http://link.springer.com/article/10.1186/s12902-018-0332-5Blood pressureCardiovascular risk factorDBPGLP-1RAsLiraglutideSBP |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xu Zhao Kun Huang Meijie Zheng Junting Duan |
spellingShingle |
Xu Zhao Kun Huang Meijie Zheng Junting Duan Effect of liraglutide on blood pressure: a meta-analysis of liraglutide randomized controlled trials BMC Endocrine Disorders Blood pressure Cardiovascular risk factor DBP GLP-1RAs Liraglutide SBP |
author_facet |
Xu Zhao Kun Huang Meijie Zheng Junting Duan |
author_sort |
Xu Zhao |
title |
Effect of liraglutide on blood pressure: a meta-analysis of liraglutide randomized controlled trials |
title_short |
Effect of liraglutide on blood pressure: a meta-analysis of liraglutide randomized controlled trials |
title_full |
Effect of liraglutide on blood pressure: a meta-analysis of liraglutide randomized controlled trials |
title_fullStr |
Effect of liraglutide on blood pressure: a meta-analysis of liraglutide randomized controlled trials |
title_full_unstemmed |
Effect of liraglutide on blood pressure: a meta-analysis of liraglutide randomized controlled trials |
title_sort |
effect of liraglutide on blood pressure: a meta-analysis of liraglutide randomized controlled trials |
publisher |
BMC |
series |
BMC Endocrine Disorders |
issn |
1472-6823 |
publishDate |
2019-01-01 |
description |
Abstract Background Several clinical trials have studied the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on glycometabolism and cardiovascular risk factors since they were identified. Because of their cardiovascular benefits and efficacy in lowering glucose, GLP-1RAs are becoming increasingly important in clinical therapy for patients with or without pathoglycaemia. The aim of this study was to assess the effect of the GLP-1RA liraglutide on blood pressure based on randomised controlled trials (RCTs). Methods We searched PubMed for RCTs published from 2009 to 2018 comparing the effect of liraglutide on blood pressure with that of placebo in individuals with or without pathoglycaemia. RCTs in humans that included data describing blood pressure changes from baseline to the end of the trial were selected for inclusion in the meta-analysis. Results A total of 18 RCTs that enrolled 7616 individuals in the liraglutide group and 6046 individuals in the control group were included in this meta-analysis. Compared with placebo, liraglutide reduced systolic blood pressure (SBP) by 3.18 mmHg (95% CI -4.32, − 2.05), P < 0.00001, but had no significant effect on diastolic blood pressure (DBP). Subgroup analysis showed that the degree of reduction in SBP was associated with the dose of liraglutide but that significance disappeared when the intervention lasted over 1 year. Liraglutide 3.0 mg/d significantly reduced DBP by 1.46 mmHg (95% CI -2.61, 0.32), P = 0.01, but liraglutide 1.8 mg/d slightly increased DBP by 0.47 mmHg (95% CI 0.11, 0.83), P = 0.01, compared with placebo. Conclusions This meta-analysis demonstrated that liraglutide significantly reduced SBP in individuals with or without pathoglycaemia compared with placebo, but the difference was no longer significant when the intervention lasted over 1 year. Moreover, the effect of liraglutide on blood pressure is associated with the dose. This finding may provide additional evidence for cardiovascular protection. |
topic |
Blood pressure Cardiovascular risk factor DBP GLP-1RAs Liraglutide SBP |
url |
http://link.springer.com/article/10.1186/s12902-018-0332-5 |
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