Poly-γ-Glutamic Acid Complexed With Alum Induces Cross-Protective Immunity of Pandemic H1N1 Vaccine

Poly-γ-Glutamic Acid Complexed With Alum Induces Cross-Protective Immunity of Pandemic H1N1 Vaccine

The use of a good vaccine adjuvant may induce a higher immunogenicity profile of vaccine antigens. Here, we developed a new adjuvant by combining poly-γ-glutamic acid (γ-PGA) with alum (PGA/Alum) and investigated its ability to enhance the immunogenicity and the cross-reactive efficacy of pandemic H...

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Bibliographic Details
Main Authors: Quyen Thi Nguyen, Chaewon Kwak, Wang Sik Lee, Jaemoo Kim, Jinyoung Jeong, Moon Hee Sung, Jihyun Yang, Haryoung Poo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
vaccine adjuvant
influenza virus
efficacy
cross-protection
antibody-dependent cellular cytotoxicity
cytotoxic T lymphocyte activity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01604/full

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