<i>Clostridium perfringens</i> as Foodborne Pathogen in Broiler Production: Pathophysiology and Potential Strategies for Controlling Necrotic Enteritis
<i>Clostridium perfringens</i> (Cp.) is the cause of human foodborne desease. Meat and poultry products are identified as the main source of infection for humans. Cp. can be found in poultry litter, feces, soil, dust, and healthy birds’ intestinal contents. Cp. strains are known to secre...
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doaj-625c63eb5fb94089b4b5bbf5fe5cac152020-11-25T02:35:50ZengMDPI AGAnimals2076-26152020-09-01101718171810.3390/ani10091718<i>Clostridium perfringens</i> as Foodborne Pathogen in Broiler Production: Pathophysiology and Potential Strategies for Controlling Necrotic EnteritisZuamí Villagrán-de la Mora0María Esther Macías-Rodríguez1Jenny Arratia-Quijada2Yesica Sughey Gonzalez-Torres3Karla Nuño4Angélica Villarruel-López5Departamento de Ciencias de la Salud, Centro Universitario de Los Altos, Universidad de Guadalajara, Av. Rafael Casillas Aceves 1200, Tepatitlán de Morelos 47620, MexicoDepartamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Blvd. Gral. Marcelino García Barragán 1421, Olímpica 44430, Guadalajara, MexicoDepartamento de Ciencias Biomédicas, Centro Universitario de Tonalá, Universidad de Guadalajara, Nuevo Perif. Ote. 555, Ejido San José, Tateposco 45425, Tonalá, MexicoDepartamento de Ciencias de la Salud, Centro Universitario de Los Altos, Universidad de Guadalajara, Av. Rafael Casillas Aceves 1200, Tepatitlán de Morelos 47620, MexicoDepartamento de Ciencias Biomédicas, Centro Universitario de Tonalá, Universidad de Guadalajara, Nuevo Perif. Ote. 555, Ejido San José, Tateposco 45425, Tonalá, MexicoDepartamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Blvd. Gral. Marcelino García Barragán 1421, Olímpica 44430, Guadalajara, Mexico<i>Clostridium perfringens</i> (Cp.) is the cause of human foodborne desease. Meat and poultry products are identified as the main source of infection for humans. Cp. can be found in poultry litter, feces, soil, dust, and healthy birds’ intestinal contents. Cp. strains are known to secrete over 20 identified toxins and enzymes that could potentially be the principal virulence factors, capable of degrading mucin, affecting enterocytes, and the small intestine epithelium, involved in necrotic enteritis (NE) pathophysiology, also leading to immunological responses, microbiota modification and anatomical changes. Different environmental and dietary factors can determine the colonization of this microorganism. It has been observed that the incidence of Cp-associated to NE in broilers has increased in countries that have stopped using antibiotic growth promoters. Since the banning of such antibiotic growth promoters, several strategies for Cp. control have been proposed, including dietary modifications, probiotics, prebiotics, synbiotics, phytogenics, organic acids, and vaccines. However, there are aspects of the pathology that still need to be clarified to establish better actions to control and prevention. This paper reviews the current knowledge about Cp. as foodborne pathogen, the pathophysiology of NE, and recent findings on potential strategies for its control.https://www.mdpi.com/2076-2615/10/9/1718<i>C. perfringens</i>necrotic enteritispathophysiologycontrol strategies |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zuamí Villagrán-de la Mora María Esther Macías-Rodríguez Jenny Arratia-Quijada Yesica Sughey Gonzalez-Torres Karla Nuño Angélica Villarruel-López |
spellingShingle |
Zuamí Villagrán-de la Mora María Esther Macías-Rodríguez Jenny Arratia-Quijada Yesica Sughey Gonzalez-Torres Karla Nuño Angélica Villarruel-López <i>Clostridium perfringens</i> as Foodborne Pathogen in Broiler Production: Pathophysiology and Potential Strategies for Controlling Necrotic Enteritis Animals <i>C. perfringens</i> necrotic enteritis pathophysiology control strategies |
author_facet |
Zuamí Villagrán-de la Mora María Esther Macías-Rodríguez Jenny Arratia-Quijada Yesica Sughey Gonzalez-Torres Karla Nuño Angélica Villarruel-López |
author_sort |
Zuamí Villagrán-de la Mora |
title |
<i>Clostridium perfringens</i> as Foodborne Pathogen in Broiler Production: Pathophysiology and Potential Strategies for Controlling Necrotic Enteritis |
title_short |
<i>Clostridium perfringens</i> as Foodborne Pathogen in Broiler Production: Pathophysiology and Potential Strategies for Controlling Necrotic Enteritis |
title_full |
<i>Clostridium perfringens</i> as Foodborne Pathogen in Broiler Production: Pathophysiology and Potential Strategies for Controlling Necrotic Enteritis |
title_fullStr |
<i>Clostridium perfringens</i> as Foodborne Pathogen in Broiler Production: Pathophysiology and Potential Strategies for Controlling Necrotic Enteritis |
title_full_unstemmed |
<i>Clostridium perfringens</i> as Foodborne Pathogen in Broiler Production: Pathophysiology and Potential Strategies for Controlling Necrotic Enteritis |
title_sort |
<i>clostridium perfringens</i> as foodborne pathogen in broiler production: pathophysiology and potential strategies for controlling necrotic enteritis |
publisher |
MDPI AG |
series |
Animals |
issn |
2076-2615 |
publishDate |
2020-09-01 |
description |
<i>Clostridium perfringens</i> (Cp.) is the cause of human foodborne desease. Meat and poultry products are identified as the main source of infection for humans. Cp. can be found in poultry litter, feces, soil, dust, and healthy birds’ intestinal contents. Cp. strains are known to secrete over 20 identified toxins and enzymes that could potentially be the principal virulence factors, capable of degrading mucin, affecting enterocytes, and the small intestine epithelium, involved in necrotic enteritis (NE) pathophysiology, also leading to immunological responses, microbiota modification and anatomical changes. Different environmental and dietary factors can determine the colonization of this microorganism. It has been observed that the incidence of Cp-associated to NE in broilers has increased in countries that have stopped using antibiotic growth promoters. Since the banning of such antibiotic growth promoters, several strategies for Cp. control have been proposed, including dietary modifications, probiotics, prebiotics, synbiotics, phytogenics, organic acids, and vaccines. However, there are aspects of the pathology that still need to be clarified to establish better actions to control and prevention. This paper reviews the current knowledge about Cp. as foodborne pathogen, the pathophysiology of NE, and recent findings on potential strategies for its control. |
topic |
<i>C. perfringens</i> necrotic enteritis pathophysiology control strategies |
url |
https://www.mdpi.com/2076-2615/10/9/1718 |
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