Contrasting roles for CD4 vs. CD8 T-cells in a murine model of virally induced "T1 black hole" formation.

Contrasting roles for CD4 vs. CD8 T-cells in a murine model of virally induced "T1 black hole" formation.

MRI is sensitive to tissue pathology in multiple sclerosis (MS); however, most lesional MRI findings have limited correlation with disability. Chronic T1 hypointense lesions or "T1 black holes" (T1BH), observed in a subset of MS patients and thought to represent axonal damage, show moderat...

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Bibliographic Details
Main Authors: Istvan Pirko, Yi Chen, Anne K Lohrey, Jeremiah McDole, Jeffrey D Gamez, Kathleen S Allen, Kevin D Pavelko, Diana M Lindquist, R Scott Dunn, Slobodan I Macura, Aaron J Johnson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3278445?pdf=render

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