Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort
Casting-type calcifications and a histopathological picture with cancer-filled duct-like structures have been presented as breast cancer with neoductgenesis. We correlated mammographic features and histopathological neoductgenesis with prognosis in a DCIS cohort with long follow-up. Mammographic fea...
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doaj-6263e10802774a7f876133814470fef22020-11-24T23:56:18ZengHindawi LimitedInternational Journal of Breast Cancer2090-31702090-31892017-01-01201710.1155/2017/43513194351319Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based CohortWenjing Zhou0Thomas Sollie1Tibor Tot2Carl Blomqvist3Shahin Abdsaleh4Göran Liljegren5Fredrik Wärnberg6Department of Surgical Sciences, Uppsala University, Uppsala Academic Hospital, Uppsala, SwedenDepartment of Pathology, Örebro University, Örebro, SwedenDepartment of Pathology, Falun Central Hospital, Falun, SwedenDepartment of Oncology, Helsinki University Central Hospital, Helsinki, FinlandDepartment of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, SwedenDepartment of Surgery, Örebro University, Örebro, SwedenDepartment of Surgical Sciences, Uppsala University, Uppsala Academic Hospital, Uppsala, SwedenCasting-type calcifications and a histopathological picture with cancer-filled duct-like structures have been presented as breast cancer with neoductgenesis. We correlated mammographic features and histopathological neoductgenesis with prognosis in a DCIS cohort with long follow-up. Mammographic features were classified into seven groups according to Tabár. Histopathological neoductgenesis was defined by concentration of ducts, lymphocyte infiltration, and periductal fibrosis. Endpoints were ipsilateral (IBE) in situ and invasive events. Casting-type calcifications and neoductgenesis were both related to high nuclear grade, ER- and PR-negativity, and HER2 overexpression but not to each other. Casting-type calcifications and neoductgenesis were both related to a nonsignificant lower risk of invasive IBE, HR 0.38 (0.13–1.08) and 0.82 (0.29–2.27), respectively, and the HR of an in situ IBE was 0.90 (0.41–1.95) and 1.60 (0.75–3.39), respectively. Casting-type calcifications could not be related to a worse prognosis in DCIS. We cannot explain why a more aggressive phenotype of DCIS did not correspond to a worse prognosis. Further studies on how the progression from in situ to invasive carcinoma is driven are needed.http://dx.doi.org/10.1155/2017/4351319 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wenjing Zhou Thomas Sollie Tibor Tot Carl Blomqvist Shahin Abdsaleh Göran Liljegren Fredrik Wärnberg |
spellingShingle |
Wenjing Zhou Thomas Sollie Tibor Tot Carl Blomqvist Shahin Abdsaleh Göran Liljegren Fredrik Wärnberg Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort International Journal of Breast Cancer |
author_facet |
Wenjing Zhou Thomas Sollie Tibor Tot Carl Blomqvist Shahin Abdsaleh Göran Liljegren Fredrik Wärnberg |
author_sort |
Wenjing Zhou |
title |
Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort |
title_short |
Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort |
title_full |
Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort |
title_fullStr |
Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort |
title_full_unstemmed |
Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort |
title_sort |
ductal breast carcinoma in situ: mammographic features and its relation to prognosis and tumour biology in a population based cohort |
publisher |
Hindawi Limited |
series |
International Journal of Breast Cancer |
issn |
2090-3170 2090-3189 |
publishDate |
2017-01-01 |
description |
Casting-type calcifications and a histopathological picture with cancer-filled duct-like structures have been presented as breast cancer with neoductgenesis. We correlated mammographic features and histopathological neoductgenesis with prognosis in a DCIS cohort with long follow-up. Mammographic features were classified into seven groups according to Tabár. Histopathological neoductgenesis was defined by concentration of ducts, lymphocyte infiltration, and periductal fibrosis. Endpoints were ipsilateral (IBE) in situ and invasive events. Casting-type calcifications and neoductgenesis were both related to high nuclear grade, ER- and PR-negativity, and HER2 overexpression but not to each other. Casting-type calcifications and neoductgenesis were both related to a nonsignificant lower risk of invasive IBE, HR 0.38 (0.13–1.08) and 0.82 (0.29–2.27), respectively, and the HR of an in situ IBE was 0.90 (0.41–1.95) and 1.60 (0.75–3.39), respectively. Casting-type calcifications could not be related to a worse prognosis in DCIS. We cannot explain why a more aggressive phenotype of DCIS did not correspond to a worse prognosis. Further studies on how the progression from in situ to invasive carcinoma is driven are needed. |
url |
http://dx.doi.org/10.1155/2017/4351319 |
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