Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications
Skeletal muscle is capable of secreting different factors in order to communicate with other tissues. These mediators, the myokines, show potentially far-reaching effects on non-muscle tissues and can provide a molecular interaction between muscle and body physiology. Sarcopenia is a chronic degener...
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Format: | Article |
Language: | English |
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MDPI AG
2020-05-01
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Series: | International Journal of Molecular Sciences |
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Online Access: | https://www.mdpi.com/1422-0067/21/10/3607 |
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doaj-6264ec51313a4bab97ebb0b67ae3f38e |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sandra Maria Barbalho Uri Adrian Prync Flato Ricardo José Tofano Ricardo de Alvares Goulart Elen Landgraf Guiguer Cláudia Rucco P. Detregiachi Daniela Vieira Buchaim Adriano Cressoni Araújo Rogério Leone Buchain Fábio Tadeu Rodrigues Reina Piero Biteli Daniela O. B. Rodrigues Reina Marcelo Dib Bechara |
spellingShingle |
Sandra Maria Barbalho Uri Adrian Prync Flato Ricardo José Tofano Ricardo de Alvares Goulart Elen Landgraf Guiguer Cláudia Rucco P. Detregiachi Daniela Vieira Buchaim Adriano Cressoni Araújo Rogério Leone Buchain Fábio Tadeu Rodrigues Reina Piero Biteli Daniela O. B. Rodrigues Reina Marcelo Dib Bechara Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications International Journal of Molecular Sciences sarcopenia myokines cardiovascular diseases |
author_facet |
Sandra Maria Barbalho Uri Adrian Prync Flato Ricardo José Tofano Ricardo de Alvares Goulart Elen Landgraf Guiguer Cláudia Rucco P. Detregiachi Daniela Vieira Buchaim Adriano Cressoni Araújo Rogério Leone Buchain Fábio Tadeu Rodrigues Reina Piero Biteli Daniela O. B. Rodrigues Reina Marcelo Dib Bechara |
author_sort |
Sandra Maria Barbalho |
title |
Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications |
title_short |
Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications |
title_full |
Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications |
title_fullStr |
Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications |
title_full_unstemmed |
Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications |
title_sort |
physical exercise and myokines: relationships with sarcopenia and cardiovascular complications |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-05-01 |
description |
Skeletal muscle is capable of secreting different factors in order to communicate with other tissues. These mediators, the myokines, show potentially far-reaching effects on non-muscle tissues and can provide a molecular interaction between muscle and body physiology. Sarcopenia is a chronic degenerative neuromuscular disease closely related to cardiomyopathy and chronic heart failure, which influences the production and release of myokines. Our objective was to explore the relationship between myokines, sarcopenia, and cardiovascular diseases (CVD). The autocrine, paracrine, and endocrine actions of myokines include regulation of energy expenditure, insulin sensitivity, lipolysis, free fatty acid oxidation, adipocyte browning, glycogenolysis, glycogenesis, and general metabolism. A sedentary lifestyle accelerates the aging process and is a risk factor for developing sarcopenia, metabolic syndrome, and CVD. Increased adipose tissue resulting from the decrease in muscle mass in patients with sarcopenia may also be involved in the pathology of CVD. Myokines are protagonists in the complex condition of sarcopenia, which is associated with adverse clinical outcomes in patients with CVD. The discovery of new pathways and the link between myokines and CVD remain a cornerstone toward multifaceted interventions and perhaps the minimization of the damage resulting from muscle loss induced by factors such as atherosclerosis. |
topic |
sarcopenia myokines cardiovascular diseases |
url |
https://www.mdpi.com/1422-0067/21/10/3607 |
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doaj-6264ec51313a4bab97ebb0b67ae3f38e2020-11-25T03:26:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-01213607360710.3390/ijms21103607Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular ComplicationsSandra Maria Barbalho0Uri Adrian Prync Flato1Ricardo José Tofano2Ricardo de Alvares Goulart3Elen Landgraf Guiguer4Cláudia Rucco P. Detregiachi5Daniela Vieira Buchaim6Adriano Cressoni Araújo7Rogério Leone Buchain8Fábio Tadeu Rodrigues Reina9Piero Biteli10Daniela O. B. Rodrigues Reina11Marcelo Dib Bechara12Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Avenue Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Avenue Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Avenue Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Avenue Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Avenue Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Avenue Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Avenue Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Avenue Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Avenue Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Avenue Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Avenue Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Avenue Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, BrazilSchool of Medicine, University of Marília (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marília 17506-000, São Paulo, BrazilSkeletal muscle is capable of secreting different factors in order to communicate with other tissues. These mediators, the myokines, show potentially far-reaching effects on non-muscle tissues and can provide a molecular interaction between muscle and body physiology. Sarcopenia is a chronic degenerative neuromuscular disease closely related to cardiomyopathy and chronic heart failure, which influences the production and release of myokines. Our objective was to explore the relationship between myokines, sarcopenia, and cardiovascular diseases (CVD). The autocrine, paracrine, and endocrine actions of myokines include regulation of energy expenditure, insulin sensitivity, lipolysis, free fatty acid oxidation, adipocyte browning, glycogenolysis, glycogenesis, and general metabolism. A sedentary lifestyle accelerates the aging process and is a risk factor for developing sarcopenia, metabolic syndrome, and CVD. Increased adipose tissue resulting from the decrease in muscle mass in patients with sarcopenia may also be involved in the pathology of CVD. Myokines are protagonists in the complex condition of sarcopenia, which is associated with adverse clinical outcomes in patients with CVD. The discovery of new pathways and the link between myokines and CVD remain a cornerstone toward multifaceted interventions and perhaps the minimization of the damage resulting from muscle loss induced by factors such as atherosclerosis.https://www.mdpi.com/1422-0067/21/10/3607sarcopeniamyokinescardiovascular diseases |