Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R.

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R.

The Leiden Longevity Study consists of families that express extended survival across generations, decreased morbidity in middle-age, and beneficial metabolic profiles. To identify which pathways drive this complex phenotype of familial longevity and healthy aging, we performed a genome-wide gene ex...

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Main Authors: Willemijn M Passtoors, Judith M Boer, Jelle J Goeman, Erik B van den Akker, Joris Deelen, Bas J Zwaan, Ann Scarborough, Ruud van der Breggen, Rolf H A M Vossen, Jeanine J Houwing-Duistermaat, Gert Jan B van Ommen, Rudi G J Westendorp, Diana van Heemst, Anton J M de Craen, Andrew J White, David A Gunn, Marian Beekman, P Eline Slagboom
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3256132?pdf=render

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