Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway.
Our previous studies suggest that Th17 cells accumulate within tumor tissues and correlate with recurrence of cervical cancer patients. However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood. We investigated the prevalence, phenotype and trafficking property of...
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doaj-626dbc60664641dd916ce96a89440b072020-11-25T00:50:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e012085510.1371/journal.pone.0120855Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway.Qing YuXiang-ming LouYan HeOur previous studies suggest that Th17 cells accumulate within tumor tissues and correlate with recurrence of cervical cancer patients. However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood. We investigated the prevalence, phenotype and trafficking property of Th17 cells in patients with cervical cancer. Our results showed that Th17 cells highly aggregated within tumor tissues in an activated phenotype with markedly increased expression of CCR6. Correspondingly, level of CCL20 in the tumor tissues was significantly higher than that in non-tumor and normal control tissues, and strongly positively associated with Th17 cells. Further, in vitro migration assay showed CCL20 had effective chemotaxis to circulating Th17 cells. In conclusion, Th17 cells are recruited into tumor tissues preferentially through CCR6-CCL20 pathway, which can serve as a novel therapeutic target for cervical cancer.http://europepmc.org/articles/PMC4359139?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qing Yu Xiang-ming Lou Yan He |
spellingShingle |
Qing Yu Xiang-ming Lou Yan He Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. PLoS ONE |
author_facet |
Qing Yu Xiang-ming Lou Yan He |
author_sort |
Qing Yu |
title |
Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. |
title_short |
Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. |
title_full |
Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. |
title_fullStr |
Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. |
title_full_unstemmed |
Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. |
title_sort |
preferential recruitment of th17 cells to cervical cancer via ccr6-ccl20 pathway. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
Our previous studies suggest that Th17 cells accumulate within tumor tissues and correlate with recurrence of cervical cancer patients. However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood. We investigated the prevalence, phenotype and trafficking property of Th17 cells in patients with cervical cancer. Our results showed that Th17 cells highly aggregated within tumor tissues in an activated phenotype with markedly increased expression of CCR6. Correspondingly, level of CCL20 in the tumor tissues was significantly higher than that in non-tumor and normal control tissues, and strongly positively associated with Th17 cells. Further, in vitro migration assay showed CCL20 had effective chemotaxis to circulating Th17 cells. In conclusion, Th17 cells are recruited into tumor tissues preferentially through CCR6-CCL20 pathway, which can serve as a novel therapeutic target for cervical cancer. |
url |
http://europepmc.org/articles/PMC4359139?pdf=render |
work_keys_str_mv |
AT qingyu preferentialrecruitmentofth17cellstocervicalcancerviaccr6ccl20pathway AT xiangminglou preferentialrecruitmentofth17cellstocervicalcancerviaccr6ccl20pathway AT yanhe preferentialrecruitmentofth17cellstocervicalcancerviaccr6ccl20pathway |
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