Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study
Aim:It is known that muscle mass decreases with age. Sometimes it may be possible to adversely affect this reduction. It was aimed to investigate the contribution of claudin-5 and E-cadherin to this process.Methods:Samples were taken from the psoas muscle of 55 cases autopsied for different reasons...
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Galenos Yayinevi
2021-09-01
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doaj-626df1afebf540c5b3add80a9dd7bfaf2021-09-14T08:15:56ZengGalenos YayineviHaseki Tıp Bülteni1302-00722147-26882021-09-0159428028510.4274/haseki.galenos.2021.717413049054Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy StudyHavva Erdem0Hacer Yasar Teke1Yusuf Sahin2 Ordu Unıversıty Faculty of Medicine, Department of Medıcal Pathology, Ordu, Turkey Ordu Unıversıty Faculty of Medicine, Department of Forensıc Medıcıne, Ordu, Turkey Directorate of Forensic Medicine, Forensıc Medıcıne, Ordu, Turkey Aim:It is known that muscle mass decreases with age. Sometimes it may be possible to adversely affect this reduction. It was aimed to investigate the contribution of claudin-5 and E-cadherin to this process.Methods:Samples were taken from the psoas muscle of 55 cases autopsied for different reasons between 2018-2019. Age, gender, weight, height, chronic disease, and addiction were recorded. Histopathological degeneration parameters were evaluated. In addition, samples were prepared for immunohistochemical study. Evaluation for E-cadherin and claudin-5; no staining, weak staining, moderate staining and severe staining. Fibrosis was evaluated with Masson trichrome.Results:There was a very strong and statistically significant inverse relationship between acidophilic sarcoplasma and staining with claudin-5 (p<0.01). There was also a strong positive correlation between cellular fatty cell degeneration status and staining with claudin-5 (p=0.04). No correlation could be established between sociodemographic characteristics of the cases and staining with claudin-5 and E-cadherin, nor could there be a correlation between staining with E-cadherin and staining with claudin-5 (p>0.05).Conclusion:Claudin-5 can be a target protein that can be used in the detection and prophylaxis of degeneration and atrophy in striated muscles. http://www.hasekidergisi.com/archives/archive-detail/article-preview/evaluation-of-fibrosis-and-histopathological-chang/48295 claudin-5cadherinssocioeconomic factorsmusclestriated |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Havva Erdem Hacer Yasar Teke Yusuf Sahin |
spellingShingle |
Havva Erdem Hacer Yasar Teke Yusuf Sahin Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study Haseki Tıp Bülteni claudin-5 cadherins socioeconomic factors muscle striated |
author_facet |
Havva Erdem Hacer Yasar Teke Yusuf Sahin |
author_sort |
Havva Erdem |
title |
Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study |
title_short |
Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study |
title_full |
Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study |
title_fullStr |
Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study |
title_full_unstemmed |
Evaluation of Fibrosis and Histopathological Changes in the Psoas Muscle with E- Cadherin, Claudin-5 Expression and Demographic Data: An Autopsy Study |
title_sort |
evaluation of fibrosis and histopathological changes in the psoas muscle with e- cadherin, claudin-5 expression and demographic data: an autopsy study |
publisher |
Galenos Yayinevi |
series |
Haseki Tıp Bülteni |
issn |
1302-0072 2147-2688 |
publishDate |
2021-09-01 |
description |
Aim:It is known that muscle mass decreases with age. Sometimes it may be possible to adversely affect this reduction. It was aimed to investigate the contribution of claudin-5 and E-cadherin to this process.Methods:Samples were taken from the psoas muscle of 55 cases autopsied for different reasons between 2018-2019. Age, gender, weight, height, chronic disease, and addiction were recorded. Histopathological degeneration parameters were evaluated. In addition, samples were prepared for immunohistochemical study. Evaluation for E-cadherin and claudin-5; no staining, weak staining, moderate staining and severe staining. Fibrosis was evaluated with Masson trichrome.Results:There was a very strong and statistically significant inverse relationship between acidophilic sarcoplasma and staining with claudin-5 (p<0.01). There was also a strong positive correlation between cellular fatty cell degeneration status and staining with claudin-5 (p=0.04). No correlation could be established between sociodemographic characteristics of the cases and staining with claudin-5 and E-cadherin, nor could there be a correlation between staining with E-cadherin and staining with claudin-5 (p>0.05).Conclusion:Claudin-5 can be a target protein that can be used in the detection and prophylaxis of degeneration and atrophy in striated muscles. |
topic |
claudin-5 cadherins socioeconomic factors muscle striated |
url |
http://www.hasekidergisi.com/archives/archive-detail/article-preview/evaluation-of-fibrosis-and-histopathological-chang/48295
|
work_keys_str_mv |
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