Oral microbiota in youth with perinatally acquired HIV infection
Abstract Background Microbially mediated oral diseases can signal underlying HIV/AIDS progression in HIV-infected adults. The role of the oral microbiota in HIV-infected youth is not known. The Adolescent Master Protocol of the Pediatric HIV/AIDS Cohort Study is a longitudinal study of perinatally H...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-05-01
|
Series: | Microbiome |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40168-018-0484-6 |
id |
doaj-62700cfde6a4447b93edccc7826b1667 |
---|---|
record_format |
Article |
spelling |
doaj-62700cfde6a4447b93edccc7826b16672020-11-25T01:20:31ZengBMCMicrobiome2049-26182018-05-01611910.1186/s40168-018-0484-6Oral microbiota in youth with perinatally acquired HIV infectionJacqueline R. Starr0Yanmei Huang1Kyu Ha Lee2C. M. Murphy3Anna-Barbara Moscicki4Caroline H. Shiboski5Mark I. Ryder6Tzy-Jyun Yao7Lina L. Faller8Russell B. Van Dyke9Bruce J. Paster10for the Pediatric HIV/AIDS Cohort StudyForsyth InstituteForsyth InstituteForsyth InstituteForsyth InstituteDepartment of Pediatrics, David Geffen School of Medicine, University of California Los AngelesDepartment of Orofacial Sciences, School of Dentistry, University of California San FranciscoDepartment of Orofacial Sciences, School of Dentistry, University of California San FranciscoCenter for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public HealthGinkgo BioworksTulane University School of MedicineForsyth InstituteAbstract Background Microbially mediated oral diseases can signal underlying HIV/AIDS progression in HIV-infected adults. The role of the oral microbiota in HIV-infected youth is not known. The Adolescent Master Protocol of the Pediatric HIV/AIDS Cohort Study is a longitudinal study of perinatally HIV-infected (PHIV) and HIV-exposed, uninfected (PHEU) youth. We compared oral microbiome levels and associations with caries or periodontitis in 154 PHIV and 100 PHEU youth. Results Species richness and alpha diversity differed little between PHIV and PHEU youth. Group differences in average counts met the significance threshold for six taxa; two Corynebacterium species were lower in PHIV and met thresholds for noteworthiness. Several known periodontitis-associated organisms (Prevotella nigrescens, Tannerella forsythia, Aggregatibacter actinomycetemcomitans, and Filifactor alocis) exhibited expected associations with periodontitis in PHEU youth, associations not observed in PHIV youth. In both groups, odds of caries increased with counts of taxa in four genera, Streptococcus, Scardovia, Bifidobacterium, and Lactobacillus. Conclusions The microbiomes of PHIV and PHEU youth were similar, although PHIV youth seemed to have fewer “health”-associated taxa such as Corynebacterium species. These results are consistent with the hypothesis that HIV infection, or its treatment, may contribute to oral dysbiosis.http://link.springer.com/article/10.1186/s40168-018-0484-6Perinatally infected HIVPediatricOral microbiomeCorynebacterium |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jacqueline R. Starr Yanmei Huang Kyu Ha Lee C. M. Murphy Anna-Barbara Moscicki Caroline H. Shiboski Mark I. Ryder Tzy-Jyun Yao Lina L. Faller Russell B. Van Dyke Bruce J. Paster for the Pediatric HIV/AIDS Cohort Study |
spellingShingle |
Jacqueline R. Starr Yanmei Huang Kyu Ha Lee C. M. Murphy Anna-Barbara Moscicki Caroline H. Shiboski Mark I. Ryder Tzy-Jyun Yao Lina L. Faller Russell B. Van Dyke Bruce J. Paster for the Pediatric HIV/AIDS Cohort Study Oral microbiota in youth with perinatally acquired HIV infection Microbiome Perinatally infected HIV Pediatric Oral microbiome Corynebacterium |
author_facet |
Jacqueline R. Starr Yanmei Huang Kyu Ha Lee C. M. Murphy Anna-Barbara Moscicki Caroline H. Shiboski Mark I. Ryder Tzy-Jyun Yao Lina L. Faller Russell B. Van Dyke Bruce J. Paster for the Pediatric HIV/AIDS Cohort Study |
author_sort |
Jacqueline R. Starr |
title |
Oral microbiota in youth with perinatally acquired HIV infection |
title_short |
Oral microbiota in youth with perinatally acquired HIV infection |
title_full |
Oral microbiota in youth with perinatally acquired HIV infection |
title_fullStr |
Oral microbiota in youth with perinatally acquired HIV infection |
title_full_unstemmed |
Oral microbiota in youth with perinatally acquired HIV infection |
title_sort |
oral microbiota in youth with perinatally acquired hiv infection |
publisher |
BMC |
series |
Microbiome |
issn |
2049-2618 |
publishDate |
2018-05-01 |
description |
Abstract Background Microbially mediated oral diseases can signal underlying HIV/AIDS progression in HIV-infected adults. The role of the oral microbiota in HIV-infected youth is not known. The Adolescent Master Protocol of the Pediatric HIV/AIDS Cohort Study is a longitudinal study of perinatally HIV-infected (PHIV) and HIV-exposed, uninfected (PHEU) youth. We compared oral microbiome levels and associations with caries or periodontitis in 154 PHIV and 100 PHEU youth. Results Species richness and alpha diversity differed little between PHIV and PHEU youth. Group differences in average counts met the significance threshold for six taxa; two Corynebacterium species were lower in PHIV and met thresholds for noteworthiness. Several known periodontitis-associated organisms (Prevotella nigrescens, Tannerella forsythia, Aggregatibacter actinomycetemcomitans, and Filifactor alocis) exhibited expected associations with periodontitis in PHEU youth, associations not observed in PHIV youth. In both groups, odds of caries increased with counts of taxa in four genera, Streptococcus, Scardovia, Bifidobacterium, and Lactobacillus. Conclusions The microbiomes of PHIV and PHEU youth were similar, although PHIV youth seemed to have fewer “health”-associated taxa such as Corynebacterium species. These results are consistent with the hypothesis that HIV infection, or its treatment, may contribute to oral dysbiosis. |
topic |
Perinatally infected HIV Pediatric Oral microbiome Corynebacterium |
url |
http://link.springer.com/article/10.1186/s40168-018-0484-6 |
work_keys_str_mv |
AT jacquelinerstarr oralmicrobiotainyouthwithperinatallyacquiredhivinfection AT yanmeihuang oralmicrobiotainyouthwithperinatallyacquiredhivinfection AT kyuhalee oralmicrobiotainyouthwithperinatallyacquiredhivinfection AT cmmurphy oralmicrobiotainyouthwithperinatallyacquiredhivinfection AT annabarbaramoscicki oralmicrobiotainyouthwithperinatallyacquiredhivinfection AT carolinehshiboski oralmicrobiotainyouthwithperinatallyacquiredhivinfection AT markiryder oralmicrobiotainyouthwithperinatallyacquiredhivinfection AT tzyjyunyao oralmicrobiotainyouthwithperinatallyacquiredhivinfection AT linalfaller oralmicrobiotainyouthwithperinatallyacquiredhivinfection AT russellbvandyke oralmicrobiotainyouthwithperinatallyacquiredhivinfection AT brucejpaster oralmicrobiotainyouthwithperinatallyacquiredhivinfection AT forthepediatrichivaidscohortstudy oralmicrobiotainyouthwithperinatallyacquiredhivinfection |
_version_ |
1725133806696923136 |