IgA Vasculitis in a Lung Cancer Patient During Chemoradiotherapy

• Main Authors: Taoka M, Ochi N, Mimura A, Ichiyama N, Nagasaki Y, Nakagawa N, Nakanishi H, Yamane H, Oshiro Y, Monobe Y, Takigawa N
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-06-01
• Series: Therapeutics and Clinical Risk Management
• Subjects: iga vasculitis; lung cancer; squamous cell carcinoma; nephritis; paraneoplastic syndrome
• Online Access: https://www.dovepress.com/iga-vasculitis-in-a-lung-cancer-patient-during-chemoradiotherapy-peer-reviewed-fulltext-article-TCRM

Masataka Taoka,1 Nobuaki Ochi,1 Ayaka Mimura,1 Naruhiko Ichiyama,1 Yasunari Nagasaki,1 Nozomu Nakagawa,1 Hidekazu Nakanishi,1 Hiromichi Yamane,1 Yoshiyuki Oshiro,2 Yasumasa Monobe,3 Nagio Takigawa1 1Department of General Internal Medicine 4, Kawasaki Medical School, Okayama, Japan; 2Department of General Internal Medicine 3, Kawasaki Medical School, Okayama, Japan; 3Department of Pathology, Kawasaki Medical School, Okayama, JapanCorrespondence: Nobuaki OchiDepartment of General Internal Medicine 4, Kawasaki Medical School, 2-6-1, Nakasange, Kita-ku, Okayama, JapanTel [phone]Email [e-mail]: A 72-year-old man with locally advanced lung squamous cell carcinoma experienced red purpura on the lower legs and hematuria when the disease progressed during definitive chemoradiotherapy. He had renal dysfunction and proteinuria. Biopsy specimens of the skin lesion and kidney revealed immunoglobulin A vasculitis. Potential causes such as paraneoplastic syndrome and cancer treatment have been proposed. The administration of steroids rapidly improved the symptoms. The presentation of immunoglobulin A vasculitis is accompanied by malignancies. Clinicians should keep this syndrome in mind, even during curative-intent treatment.Keywords: IgA vasculitis, lung cancer, squamous cell carcinoma, nephritis, paraneoplastic syndrome