Safety of Prasugrel in Indian patients – Multicentric registry of 1000 cases
Background: Clopidogrel has been the only available antiplatelet drug used along with aspirin in patients of ACS. In recent years 2 new antiplatelet drugs (Prasugrel and Ticagrelor) have become available. Prasugrel in the dose of 10 mg OD has been found to be more efficacious but with increased risk...
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doaj-627c2d71d0ac4707aa23aeff11f834542020-11-24T23:03:34ZengElsevierIndian Heart Journal0019-48322014-11-0166659860110.1016/j.ihj.2014.11.001Safety of Prasugrel in Indian patients – Multicentric registry of 1000 casesUpendra Kaul0Arvind Sethi1P. Arambam2A.K. Omar3R. Keshava4Sanjeeb Roy5Shuvanan Ray6Rakesh Jaswal7Ripan K. Gupta8Rakesh Rai Sapra9Rane Sandip Keshav10Rajpal Singh11Vineet Bhatia12Vinay Sanghi13Arun Chopra14Executive Director and Dean, Cardiology, Fortis Escorts Heart Institute, New Delhi, IndiaAssociate Consultant, Interventional Cardiology, Fortis Escorts Heart Institute, New Delhi, IndiaChief Clinical Research Coordinator, Fortis Escorts Heart Institute, New Delhi, IndiaDirector, Non Invasive Cardiology & Head of Department Heart Command & Emergency, Fortis Escorts Heart Institute, New Delhi, IndiaSenior Consultant, Department of Cardiology, Fortis Hospital, Bangalore, IndiaSenior Consultant, Department of Cardiology, Fortis Escorts Hospital, Jaipur, IndiaChief, Cardiology Intervention, Fortis Hospital, Kolkata, IndiaDirector, Department of Cardiology, Fortis Hospital, Mohali, IndiaPrincipal Consultant, Fortis Hospital, Vasant Kunj, New Delhi, IndiaSenior Consultant & Head of Interventional Cardiology, Fortis Escorts Hospital, Faridabad, IndiaDirector, Department of Cardiology, Fortis Hospital, Navi Mumbai, IndiaInterventional Cardiologist, Fortis Hospital, Bangalore, IndiaConsultant, Department of Cardiology, Fortis Hospital, Noida, IndiaAssociate Director, Department of Cardiology, Fortis Hospital, Shalimar Bagh, Delhi, IndiaDirector, Department of Cardiology, Fortis Hospital, Amritsar, IndiaBackground: Clopidogrel has been the only available antiplatelet drug used along with aspirin in patients of ACS. In recent years 2 new antiplatelet drugs (Prasugrel and Ticagrelor) have become available. Prasugrel in the dose of 10 mg OD has been found to be more efficacious but with increased risk of major bleeding. For this reason it has not gained widespread usage in ACS patients undergoing PCI. There are no systematic data on the use of Prasugrel in Indian population. Method: This is a prospective, multicentric, hospital registry of 1000 patients with ACS undergoing PCI who were administered Prasugrel. The primary safety endpoint of this study was major and minor bleeding while the efficacy endpoint is the composite of CV death, nonfatal MI, nonfatal stroke up to 30 days after PCI. Patients with high bleeding risk were excluded. Results: Most patients (91%) received loading dose of Prasugrel along with the maintenance dose getting according to the defined protocol. Patients were followed up to 30 days post procedure. Primary efficacy end point was reached in 3 patients only with two of them dying due to possible stent thrombosis and the third requiring revascularization of the target vessel for stent thrombosis. One major and 19 minor bleeding complications were recorded, with access site bleeding in 0.7% & non-access site bleeding in 1.2% of the subjects. Conclusion: Prasugrel was found to be effective & not associated with a high incidence of bleeding in the high risk ACS patients when those at a high bleeding risk were excluded.http://www.sciencedirect.com/science/article/pii/S0019483214007342PrasugrelBleedingSafety |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Upendra Kaul Arvind Sethi P. Arambam A.K. Omar R. Keshava Sanjeeb Roy Shuvanan Ray Rakesh Jaswal Ripan K. Gupta Rakesh Rai Sapra Rane Sandip Keshav Rajpal Singh Vineet Bhatia Vinay Sanghi Arun Chopra |
spellingShingle |
Upendra Kaul Arvind Sethi P. Arambam A.K. Omar R. Keshava Sanjeeb Roy Shuvanan Ray Rakesh Jaswal Ripan K. Gupta Rakesh Rai Sapra Rane Sandip Keshav Rajpal Singh Vineet Bhatia Vinay Sanghi Arun Chopra Safety of Prasugrel in Indian patients – Multicentric registry of 1000 cases Indian Heart Journal Prasugrel Bleeding Safety |
author_facet |
Upendra Kaul Arvind Sethi P. Arambam A.K. Omar R. Keshava Sanjeeb Roy Shuvanan Ray Rakesh Jaswal Ripan K. Gupta Rakesh Rai Sapra Rane Sandip Keshav Rajpal Singh Vineet Bhatia Vinay Sanghi Arun Chopra |
author_sort |
Upendra Kaul |
title |
Safety of Prasugrel in Indian patients – Multicentric registry of 1000 cases |
title_short |
Safety of Prasugrel in Indian patients – Multicentric registry of 1000 cases |
title_full |
Safety of Prasugrel in Indian patients – Multicentric registry of 1000 cases |
title_fullStr |
Safety of Prasugrel in Indian patients – Multicentric registry of 1000 cases |
title_full_unstemmed |
Safety of Prasugrel in Indian patients – Multicentric registry of 1000 cases |
title_sort |
safety of prasugrel in indian patients – multicentric registry of 1000 cases |
publisher |
Elsevier |
series |
Indian Heart Journal |
issn |
0019-4832 |
publishDate |
2014-11-01 |
description |
Background: Clopidogrel has been the only available antiplatelet drug used along with aspirin in patients of ACS. In recent years 2 new antiplatelet drugs (Prasugrel and Ticagrelor) have become available. Prasugrel in the dose of 10 mg OD has been found to be more efficacious but with increased risk of major bleeding. For this reason it has not gained widespread usage in ACS patients undergoing PCI. There are no systematic data on the use of Prasugrel in Indian population.
Method: This is a prospective, multicentric, hospital registry of 1000 patients with ACS undergoing PCI who were administered Prasugrel. The primary safety endpoint of this study was major and minor bleeding while the efficacy endpoint is the composite of CV death, nonfatal MI, nonfatal stroke up to 30 days after PCI. Patients with high bleeding risk were excluded.
Results: Most patients (91%) received loading dose of Prasugrel along with the maintenance dose getting according to the defined protocol. Patients were followed up to 30 days post procedure. Primary efficacy end point was reached in 3 patients only with two of them dying due to possible stent thrombosis and the third requiring revascularization of the target vessel for stent thrombosis. One major and 19 minor bleeding complications were recorded, with access site bleeding in 0.7% & non-access site bleeding in 1.2% of the subjects.
Conclusion: Prasugrel was found to be effective & not associated with a high incidence of bleeding in the high risk ACS patients when those at a high bleeding risk were excluded. |
topic |
Prasugrel Bleeding Safety |
url |
http://www.sciencedirect.com/science/article/pii/S0019483214007342 |
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