Detection of Early Heart Failure with Preserved Ejection Fraction (HFpEF) in Metabolic Syndrome Patients Detected as Part of a National Screening Programme in Middle Aged Subjects
Background We wished to investigate if community detected Metabolic Syndrome (MetS) is associated with the burden of incipient HFpEF in the community. Methods and Results We prospectively studied 148 consecutive MetS patients identified from the Lithuanian High Cardiovascular Risk primary prevention...
Main Authors: | , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Barcaray International
2018-01-01
|
Series: | International Cardiovascular Forum Journal |
Subjects: | |
Online Access: | https://icfjournal.org/index.php/icfj/article/view/550/550%C4%8Celutkien%C4%97.pdf |
id |
doaj-627f9699afc84008849e6b9220eecae1 |
---|---|
record_format |
Article |
spelling |
doaj-627f9699afc84008849e6b9220eecae12020-11-25T03:04:26ZengBarcaray InternationalInternational Cardiovascular Forum Journal2410-26362409-34242018-01-0113915https://doi.org/10.17987/icfj.v13i0.550Detection of Early Heart Failure with Preserved Ejection Fraction (HFpEF) in Metabolic Syndrome Patients Detected as Part of a National Screening Programme in Middle Aged SubjectsJelena Čelutkienė0Aistė Monika Jakštaitė1Jolita Badarienė2Svetlana Solovjova3Ieva Slivovskaja4Rokas Navickas5Edita Kazėnaitė6Egidija Rinkūnienė7Alma Čypienė8Jonas Misiūra9Ligita Ryliškytė10Aleksandras Laucevičius11Andrew Coats12Clinic of Cardiac and Vascular Diseases, Medical faculty, Vilnius University, Vilnius, LithuaniaClinic of Cardiac and Vascular Diseases, Medical faculty, Vilnius University, Vilnius, LithuaniaClinic of Cardiac and Vascular Diseases, Medical faculty, Vilnius University, Vilnius, LithuaniaClinic of Cardiac and Vascular Diseases, Medical faculty, Vilnius University, Vilnius, LithuaniaDepartment of Rehabilitation, Physical and Sports Medicine, Vilnius University Hospital Santaros Klinikos, Vilnius, LithuaniaCentre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, LithuaniaCentre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, LithuaniaCentre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, LithuaniaCentre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, LithuaniaClinic of Cardiac and Vascular Diseases, Medical faculty, Vilnius University, Vilnius, LithuaniaClinic of Cardiac and Vascular Diseases, Medical faculty, Vilnius University, Vilnius, LithuaniaClinic of Cardiac and Vascular Diseases, Medical faculty, Vilnius University, Vilnius, LithuaniaDepartment of Medical Sciences, IRCCS San Raffaele Pisana, Rome, Italy.Background We wished to investigate if community detected Metabolic Syndrome (MetS) is associated with the burden of incipient HFpEF in the community. Methods and Results We prospectively studied 148 consecutive MetS patients identified from the Lithuanian High Cardiovascular Risk primary prevention programme and investigated them further for unknown HFpEF through cardiopulmonary stress testing as well as assessment of BNP levels and of arterial stiffness. Subjects with a peak VO2 value lower than 90% of predicted and/or BNP≥35 ng/l were categorized as having early phase HFpEF. For comparison of this early phase HFpEF with others already clinically diagnosed with HFpEF, patients with both established HFpEF and MetS were selected retrospectively from patients attending our cardiopulmonary stress testing laboratory (n=38). Two thirds of the screening programme-derived MetS population (n=96) demonstrated a reduced exercise capacity and/or an elevated BNP, indicating signs of early HFpEF. Both the clinically diagnosed HFpEF and the screening programme detected MetS group with early HFpEF demonstrated similarly decreased exercise tolerance evaluated by peak oxygen uptake (79.8 ± 22.1% vs 82.7 ± 14.0%, p>0.05). Analysis of arterial markers in the screening programme group revealed statistically significant differences of augmentation index values between groups with and without signs of early HFpEF (p=0.016). Conclusions A considerable proportion of patients having MetS may be diagnosed with previously undetected early stage HFpEF. The use of objective parameters of exercise capacity and neurohormonal activation might be effectively used for the early detection of HFpEF. Also early HFpEF in this setting is found to be associated with increased arterial stiffness.https://icfjournal.org/index.php/icfj/article/view/550/550%C4%8Celutkien%C4%97.pdfheart failure with preserved ejection fractionmetabolic syndromearterial stiffnessearly detection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jelena Čelutkienė Aistė Monika Jakštaitė Jolita Badarienė Svetlana Solovjova Ieva Slivovskaja Rokas Navickas Edita Kazėnaitė Egidija Rinkūnienė Alma Čypienė Jonas Misiūra Ligita Ryliškytė Aleksandras Laucevičius Andrew Coats |
spellingShingle |
Jelena Čelutkienė Aistė Monika Jakštaitė Jolita Badarienė Svetlana Solovjova Ieva Slivovskaja Rokas Navickas Edita Kazėnaitė Egidija Rinkūnienė Alma Čypienė Jonas Misiūra Ligita Ryliškytė Aleksandras Laucevičius Andrew Coats Detection of Early Heart Failure with Preserved Ejection Fraction (HFpEF) in Metabolic Syndrome Patients Detected as Part of a National Screening Programme in Middle Aged Subjects International Cardiovascular Forum Journal heart failure with preserved ejection fraction metabolic syndrome arterial stiffness early detection |
author_facet |
Jelena Čelutkienė Aistė Monika Jakštaitė Jolita Badarienė Svetlana Solovjova Ieva Slivovskaja Rokas Navickas Edita Kazėnaitė Egidija Rinkūnienė Alma Čypienė Jonas Misiūra Ligita Ryliškytė Aleksandras Laucevičius Andrew Coats |
author_sort |
Jelena Čelutkienė |
title |
Detection of Early Heart Failure with Preserved Ejection Fraction (HFpEF) in Metabolic Syndrome Patients Detected as Part of a National Screening Programme in Middle Aged Subjects |
title_short |
Detection of Early Heart Failure with Preserved Ejection Fraction (HFpEF) in Metabolic Syndrome Patients Detected as Part of a National Screening Programme in Middle Aged Subjects |
title_full |
Detection of Early Heart Failure with Preserved Ejection Fraction (HFpEF) in Metabolic Syndrome Patients Detected as Part of a National Screening Programme in Middle Aged Subjects |
title_fullStr |
Detection of Early Heart Failure with Preserved Ejection Fraction (HFpEF) in Metabolic Syndrome Patients Detected as Part of a National Screening Programme in Middle Aged Subjects |
title_full_unstemmed |
Detection of Early Heart Failure with Preserved Ejection Fraction (HFpEF) in Metabolic Syndrome Patients Detected as Part of a National Screening Programme in Middle Aged Subjects |
title_sort |
detection of early heart failure with preserved ejection fraction (hfpef) in metabolic syndrome patients detected as part of a national screening programme in middle aged subjects |
publisher |
Barcaray International |
series |
International Cardiovascular Forum Journal |
issn |
2410-2636 2409-3424 |
publishDate |
2018-01-01 |
description |
Background We wished to investigate if community detected Metabolic Syndrome (MetS) is associated with the burden of incipient HFpEF in the community. Methods and Results We prospectively studied 148 consecutive MetS patients identified from the Lithuanian High Cardiovascular Risk primary prevention programme and investigated them further for unknown HFpEF through cardiopulmonary stress testing as well as assessment of BNP levels and of arterial stiffness. Subjects with a peak VO2 value lower than 90% of predicted and/or BNP≥35 ng/l were categorized as having early phase HFpEF. For comparison of this early phase HFpEF with others already clinically diagnosed with HFpEF, patients with both established HFpEF and MetS were selected retrospectively from patients attending our cardiopulmonary stress testing laboratory (n=38). Two thirds of the screening programme-derived MetS population (n=96) demonstrated a reduced exercise capacity and/or an elevated BNP, indicating signs of early HFpEF. Both the clinically diagnosed HFpEF and the screening programme detected MetS group with early HFpEF demonstrated similarly decreased exercise tolerance evaluated by peak oxygen uptake (79.8 ± 22.1% vs 82.7 ± 14.0%, p>0.05). Analysis of arterial markers in the screening programme group revealed statistically significant differences of augmentation index values between groups with and without signs of early HFpEF (p=0.016). Conclusions A considerable proportion of patients having MetS may be diagnosed with previously undetected early stage HFpEF. The use of objective parameters of exercise capacity and neurohormonal activation might be effectively used for the early detection of HFpEF. Also early HFpEF in this setting is found to be associated with increased arterial stiffness. |
topic |
heart failure with preserved ejection fraction metabolic syndrome arterial stiffness early detection |
url |
https://icfjournal.org/index.php/icfj/article/view/550/550%C4%8Celutkien%C4%97.pdf |
work_keys_str_mv |
AT jelenacelutkiene detectionofearlyheartfailurewithpreservedejectionfractionhfpefinmetabolicsyndromepatientsdetectedaspartofanationalscreeningprogrammeinmiddleagedsubjects AT aistemonikajakstaite detectionofearlyheartfailurewithpreservedejectionfractionhfpefinmetabolicsyndromepatientsdetectedaspartofanationalscreeningprogrammeinmiddleagedsubjects AT jolitabadariene detectionofearlyheartfailurewithpreservedejectionfractionhfpefinmetabolicsyndromepatientsdetectedaspartofanationalscreeningprogrammeinmiddleagedsubjects AT svetlanasolovjova detectionofearlyheartfailurewithpreservedejectionfractionhfpefinmetabolicsyndromepatientsdetectedaspartofanationalscreeningprogrammeinmiddleagedsubjects AT ievaslivovskaja detectionofearlyheartfailurewithpreservedejectionfractionhfpefinmetabolicsyndromepatientsdetectedaspartofanationalscreeningprogrammeinmiddleagedsubjects AT rokasnavickas detectionofearlyheartfailurewithpreservedejectionfractionhfpefinmetabolicsyndromepatientsdetectedaspartofanationalscreeningprogrammeinmiddleagedsubjects AT editakazenaite detectionofearlyheartfailurewithpreservedejectionfractionhfpefinmetabolicsyndromepatientsdetectedaspartofanationalscreeningprogrammeinmiddleagedsubjects AT egidijarinkuniene detectionofearlyheartfailurewithpreservedejectionfractionhfpefinmetabolicsyndromepatientsdetectedaspartofanationalscreeningprogrammeinmiddleagedsubjects AT almacypiene detectionofearlyheartfailurewithpreservedejectionfractionhfpefinmetabolicsyndromepatientsdetectedaspartofanationalscreeningprogrammeinmiddleagedsubjects AT jonasmisiura detectionofearlyheartfailurewithpreservedejectionfractionhfpefinmetabolicsyndromepatientsdetectedaspartofanationalscreeningprogrammeinmiddleagedsubjects AT ligitaryliskyte detectionofearlyheartfailurewithpreservedejectionfractionhfpefinmetabolicsyndromepatientsdetectedaspartofanationalscreeningprogrammeinmiddleagedsubjects AT aleksandraslaucevicius detectionofearlyheartfailurewithpreservedejectionfractionhfpefinmetabolicsyndromepatientsdetectedaspartofanationalscreeningprogrammeinmiddleagedsubjects AT andrewcoats detectionofearlyheartfailurewithpreservedejectionfractionhfpefinmetabolicsyndromepatientsdetectedaspartofanationalscreeningprogrammeinmiddleagedsubjects |
_version_ |
1724681890324021248 |