A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer

A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer

Abstract Current safety data affirms enzalutamide does not cause clinically significant liver dysfunction that warrant therapy cessation. Therefore, clinicians should not withhold potentially successful therapy merely for suspected hepatotoxicity or PnC.

Bibliographic Details
Main Authors: Jun Liu, George Agyapong, Debashish Misra, C. Douglas Taylor, David A. Hirsh
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:Clinical Case Reports
Subjects:
adverse drug reactions
cholestasis
enzalutamide
paraneoplastic syndrome
prostate cancer
Online Access:https://doi.org/10.1002/ccr3.2427
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spelling doaj-6285a86d2e1644e8a20c7cea566387ec2020-11-25T00:44:41ZengWileyClinical Case Reports2050-09042019-11-017112068207310.1002/ccr3.2427A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancerJun Liu0George Agyapong1Debashish Misra2C. Douglas Taylor3David A. Hirsh4Harvard Medical School Boston MA USAHarvard Medical School Boston MA USAHarvard Medical School Boston MA USAHarvard Medical School Boston MA USAHarvard Medical School Boston MA USAAbstract Current safety data affirms enzalutamide does not cause clinically significant liver dysfunction that warrant therapy cessation. Therefore, clinicians should not withhold potentially successful therapy merely for suspected hepatotoxicity or PnC.https://doi.org/10.1002/ccr3.2427adverse drug reactionscholestasisenzalutamideparaneoplastic syndromeprostate cancer
collection DOAJ
language English
format Article
sources DOAJ
author Jun Liu
George Agyapong
Debashish Misra
C. Douglas Taylor
David A. Hirsh
spellingShingle Jun Liu
George Agyapong
Debashish Misra
C. Douglas Taylor
David A. Hirsh
A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
Clinical Case Reports
adverse drug reactions
cholestasis
enzalutamide
paraneoplastic syndrome
prostate cancer
author_facet Jun Liu
George Agyapong
Debashish Misra
C. Douglas Taylor
David A. Hirsh
author_sort Jun Liu
title A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
title_short A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
title_full A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
title_fullStr A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
title_full_unstemmed A rare case of idiopathic cholestasis: Clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
title_sort rare case of idiopathic cholestasis: clinical conundrums complicating enzalutamide therapy in metastatic prostate cancer
publisher Wiley
series Clinical Case Reports
issn 2050-0904
publishDate 2019-11-01
description Abstract Current safety data affirms enzalutamide does not cause clinically significant liver dysfunction that warrant therapy cessation. Therefore, clinicians should not withhold potentially successful therapy merely for suspected hepatotoxicity or PnC.
topic adverse drug reactions
cholestasis
enzalutamide
paraneoplastic syndrome
prostate cancer
url https://doi.org/10.1002/ccr3.2427
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