Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio

Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio

Expression of the Vglut2/Slc17a6 gene encoding the Vesicular glutamate transporter 2 (VGLUT2) in midbrain dopamine (DA) neurons enables these neurons to co-release glutamate in the nucleus accumbens (NAc), a feature of putative importance to drug addiction. For example, it has been shown that condit...

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Bibliographic Details
Main Authors: Maria Papathanou, Meaghan Creed, Matthijs C. Dorst, Zisis Bimpisidis, Sylvie Dumas, Hanna Pettersson, Camilla Bellone, Gilad Silberberg, Christian Lüscher, Åsa Wallén-Mackenzie
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neural Circuits
Subjects:
cocaine
amphetamine
addiction
substance use disorder
ventral tegmental area (VTA)
striatum
Online Access:https://www.frontiersin.org/article/10.3389/fncir.2018.00064/full

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