Widespread regulation of gene expression by glucocorticoids in chondrocytes from patients with osteoarthritis as determined by RNA-Seq

Widespread regulation of gene expression by glucocorticoids in chondrocytes from patients with osteoarthritis as determined by RNA-Seq

Abstract Background Intra-articular glucocorticoid (GC) injections are widely used as a symptomatic treatment for osteoarthritis (OA). However, there are also concerns about their potentially harmful effects, and their detailed effects on chondrocyte phenotype remain poorly understood. Methods We st...

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Bibliographic Details
Main Authors: Antti Pemmari, Tiina Leppänen, Mari Hämäläinen, Teemu Moilanen, Katriina Vuolteenaho, Eeva Moilanen
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
Cartilage
Chondrocyte
Glucocorticoid
RNA-Seq
Online Access:http://link.springer.com/article/10.1186/s13075-020-02289-7

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