Circulating IL-17 Level Is Positively Associated with Disease Activity in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis
Previous studies on the relationship between the circulating level of interleukin-17 (IL-17) and disease activity in systemic lupus erythematosus (SLE) were contradictory. This study is aimed at quantitatively assessing the correlation between the circulating IL-17 level and disease activity in SLE...
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doaj-6295080052414a5287e49379d3c96e7f2021-08-02T00:01:36ZengHindawi LimitedBioMed Research International2314-61412021-01-01202110.1155/2021/9952463Circulating IL-17 Level Is Positively Associated with Disease Activity in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-AnalysisRulan Yin0Rong Xu1Lei Ding2Wenjie Sui3Mei’e Niu4Mingjun Wang5Lan Xu6Haifang Wang7Chomphoonut Srirat8Department of RheumatologyDepartment of RheumatologyDepartment of Internal MedicineDepartment of NursingDepartment of NursingDepartment of RheumatologyDepartment of NursingDepartment of NursingFaculty of NursingPrevious studies on the relationship between the circulating level of interleukin-17 (IL-17) and disease activity in systemic lupus erythematosus (SLE) were contradictory. This study is aimed at quantitatively assessing the correlation between the circulating IL-17 level and disease activity in SLE patients. A systematic search for related literature was conducted via PubMed, Web of Science, EMBASE, and Cochrane Library (up to January 26, 2021). The relationship between circulating IL-17 levels and SLE activity was evaluated using Fisher’s z value, which was then converted to r. The standardized mean difference (SMD) and its 95% confidence interval (CI) were used to describe the difference between the circulating IL-17 level in patients with active and inactive SLE. STATA 16.0 was used to perform statistical analysis. Random-effects model was performed to synthesize data. Twenty-six studies involving 1,560 SLE patients were included in this review. The pooled r value was 0.38 (95% CI: 0.25-0.50; I2=83.8%, P<0.001) between the SLE activity and circulating level of IL-17. Patients with active SLE had higher level of circulating IL-17 than that of inactive (pooled SMD=0.95, 95% CI: 0.38-1.53; I2=90.5%, P<0.001). The subgroup analysis suggested that the region and detection method of circulating IL-17 might not be a source of heterogeneity. No significant publication bias was found. In summary, circulating IL-17 level has a low positive relationship with SLE activity. It is necessary to carefully consider the use of circulating IL-17 as a biomarker of the disease activity in SLE patients. The relationship between the circulating level of IL-17 and SLE activity should be further confirmed in randomized controlled studies.http://dx.doi.org/10.1155/2021/9952463 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rulan Yin Rong Xu Lei Ding Wenjie Sui Mei’e Niu Mingjun Wang Lan Xu Haifang Wang Chomphoonut Srirat |
spellingShingle |
Rulan Yin Rong Xu Lei Ding Wenjie Sui Mei’e Niu Mingjun Wang Lan Xu Haifang Wang Chomphoonut Srirat Circulating IL-17 Level Is Positively Associated with Disease Activity in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis BioMed Research International |
author_facet |
Rulan Yin Rong Xu Lei Ding Wenjie Sui Mei’e Niu Mingjun Wang Lan Xu Haifang Wang Chomphoonut Srirat |
author_sort |
Rulan Yin |
title |
Circulating IL-17 Level Is Positively Associated with Disease Activity in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis |
title_short |
Circulating IL-17 Level Is Positively Associated with Disease Activity in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis |
title_full |
Circulating IL-17 Level Is Positively Associated with Disease Activity in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis |
title_fullStr |
Circulating IL-17 Level Is Positively Associated with Disease Activity in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
Circulating IL-17 Level Is Positively Associated with Disease Activity in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis |
title_sort |
circulating il-17 level is positively associated with disease activity in patients with systemic lupus erythematosus: a systematic review and meta-analysis |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6141 |
publishDate |
2021-01-01 |
description |
Previous studies on the relationship between the circulating level of interleukin-17 (IL-17) and disease activity in systemic lupus erythematosus (SLE) were contradictory. This study is aimed at quantitatively assessing the correlation between the circulating IL-17 level and disease activity in SLE patients. A systematic search for related literature was conducted via PubMed, Web of Science, EMBASE, and Cochrane Library (up to January 26, 2021). The relationship between circulating IL-17 levels and SLE activity was evaluated using Fisher’s z value, which was then converted to r. The standardized mean difference (SMD) and its 95% confidence interval (CI) were used to describe the difference between the circulating IL-17 level in patients with active and inactive SLE. STATA 16.0 was used to perform statistical analysis. Random-effects model was performed to synthesize data. Twenty-six studies involving 1,560 SLE patients were included in this review. The pooled r value was 0.38 (95% CI: 0.25-0.50; I2=83.8%, P<0.001) between the SLE activity and circulating level of IL-17. Patients with active SLE had higher level of circulating IL-17 than that of inactive (pooled SMD=0.95, 95% CI: 0.38-1.53; I2=90.5%, P<0.001). The subgroup analysis suggested that the region and detection method of circulating IL-17 might not be a source of heterogeneity. No significant publication bias was found. In summary, circulating IL-17 level has a low positive relationship with SLE activity. It is necessary to carefully consider the use of circulating IL-17 as a biomarker of the disease activity in SLE patients. The relationship between the circulating level of IL-17 and SLE activity should be further confirmed in randomized controlled studies. |
url |
http://dx.doi.org/10.1155/2021/9952463 |
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