Triple-Negative Breast Cancer: An Update on Neoadjuvant Clinical Trials

Triple-Negative Breast Cancer: An Update on Neoadjuvant Clinical Trials

Triple-negative breast cancer (TNBC) is an aggressive malignancy with a poor prognosis despite the high rates of response to chemotherapy. This scenario highlights the need to develop novel therapies and/or treatment strategies to reduce the mortality associated with TNBC. The neoadjuvant setting pr...

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Bibliographic Details
Main Authors: Keith D. Amos, Barbara Adamo, Carey K. Anders
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:International Journal of Breast Cancer
Online Access:http://dx.doi.org/10.1155/2012/385978
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spelling doaj-629ae2c50bbf4d27ba3a99a21a2acc762020-11-25T00:34:32ZengHindawi LimitedInternational Journal of Breast Cancer2090-31702090-31892012-01-01201210.1155/2012/385978385978Triple-Negative Breast Cancer: An Update on Neoadjuvant Clinical TrialsKeith D. Amos0Barbara Adamo1Carey K. Anders2Division of Surgical Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USALineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USALineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USATriple-negative breast cancer (TNBC) is an aggressive malignancy with a poor prognosis despite the high rates of response to chemotherapy. This scenario highlights the need to develop novel therapies and/or treatment strategies to reduce the mortality associated with TNBC. The neoadjuvant setting provides a model for rapid assessment of treatment efficacy with smaller patient accruals and over shorter periods of time compared to the traditional adjuvant setting. In addition, a clear surrogate endpoint of improved survival, known as pathologic complete response, already exists in this setting. Here, we review current data from completed and ongoing neoadjuvant clinical trials for TNBC.http://dx.doi.org/10.1155/2012/385978
collection DOAJ
language English
format Article
sources DOAJ
author Keith D. Amos
Barbara Adamo
Carey K. Anders
spellingShingle Keith D. Amos
Barbara Adamo
Carey K. Anders
Triple-Negative Breast Cancer: An Update on Neoadjuvant Clinical Trials
International Journal of Breast Cancer
author_facet Keith D. Amos
Barbara Adamo
Carey K. Anders
author_sort Keith D. Amos
title Triple-Negative Breast Cancer: An Update on Neoadjuvant Clinical Trials
title_short Triple-Negative Breast Cancer: An Update on Neoadjuvant Clinical Trials
title_full Triple-Negative Breast Cancer: An Update on Neoadjuvant Clinical Trials
title_fullStr Triple-Negative Breast Cancer: An Update on Neoadjuvant Clinical Trials
title_full_unstemmed Triple-Negative Breast Cancer: An Update on Neoadjuvant Clinical Trials
title_sort triple-negative breast cancer: an update on neoadjuvant clinical trials
publisher Hindawi Limited
series International Journal of Breast Cancer
issn 2090-3170
2090-3189
publishDate 2012-01-01
description Triple-negative breast cancer (TNBC) is an aggressive malignancy with a poor prognosis despite the high rates of response to chemotherapy. This scenario highlights the need to develop novel therapies and/or treatment strategies to reduce the mortality associated with TNBC. The neoadjuvant setting provides a model for rapid assessment of treatment efficacy with smaller patient accruals and over shorter periods of time compared to the traditional adjuvant setting. In addition, a clear surrogate endpoint of improved survival, known as pathologic complete response, already exists in this setting. Here, we review current data from completed and ongoing neoadjuvant clinical trials for TNBC.
url http://dx.doi.org/10.1155/2012/385978
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AT barbaraadamo triplenegativebreastcanceranupdateonneoadjuvantclinicaltrials
AT careykanders triplenegativebreastcanceranupdateonneoadjuvantclinicaltrials
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