Drug–laboratory interaction between beta-lactam antibiotics and the galactomannan antigen test used to detect mould infections
Several studies have demonstrated that piperacillin/tazobactam produces a false-positive result for the galactomannan antigen test. However, the most recent literature has demonstrated that this interaction is no longer a concern. There is little information regarding the drug–laboratory interaction...
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doaj-62a9eeb32a17490ca3656fb1c1e2fcce2020-11-25T01:29:41ZengElsevierBrazilian Journal of Infectious Diseases1413-86702014-09-01185544547S1413-86702014000500544Drug–laboratory interaction between beta-lactam antibiotics and the galactomannan antigen test used to detect mould infectionsKristin A. Otting0Kayla R. Stover1John D. Cleary2Department of Pharmacy, University of Mississippi Medical Center, Jackson, United StatesDepartment of Pharmacy Practice, School of Pharmacy, University of Mississippi, Jackson, United States; School of Medicine, University of Mississippi Medical Center, Jackson, United States; Corresponding author at: University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, United States.School of Medicine, University of Mississippi Medical Center, Jackson, United States; Department of Pharmacy, St. Dominic-Jackson Memorial Hospital, Jackson, United StatesSeveral studies have demonstrated that piperacillin/tazobactam produces a false-positive result for the galactomannan antigen test. However, the most recent literature has demonstrated that this interaction is no longer a concern. There is little information regarding the drug–laboratory interaction with the generics of piperacillin/tazobactam or other broad-spectrum beta-lactams, such as ceftaroline, doripenem, imipenem/cilastatin, and meropenem. The purpose of this study was to determine if a drug–laboratory interaction exists with these antibiotics. Tests showed that one lot of imipenem/cilastatin by Hospira Healthcare India Private Limited produced a false-positive result for the galactomannan antigen test. All other medications tested, including piperacillin/tazobactam from seven manufacturers and imipenem/cilastatin by Hospira Inc., did not produce positive results. Since the reason for this drug–laboratory interaction with imipenem/cilastatin is unknown, more studies are needed to further investigate this interaction. Providers also should be educated of these findings: no drug–laboratory interaction with piperacillin/tazobactam and a possible drug–laboratory interaction with imipenem/cilastatin (Hospira Healthcare India Private Limited). Keywords: Piperacillin–tazobactam, Galactomannan, Beta-lactams, Drug interactionhttp://www.sciencedirect.com/science/article/pii/S1413867014000981 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kristin A. Otting Kayla R. Stover John D. Cleary |
spellingShingle |
Kristin A. Otting Kayla R. Stover John D. Cleary Drug–laboratory interaction between beta-lactam antibiotics and the galactomannan antigen test used to detect mould infections Brazilian Journal of Infectious Diseases |
author_facet |
Kristin A. Otting Kayla R. Stover John D. Cleary |
author_sort |
Kristin A. Otting |
title |
Drug–laboratory interaction between beta-lactam antibiotics and the galactomannan antigen test used to detect mould infections |
title_short |
Drug–laboratory interaction between beta-lactam antibiotics and the galactomannan antigen test used to detect mould infections |
title_full |
Drug–laboratory interaction between beta-lactam antibiotics and the galactomannan antigen test used to detect mould infections |
title_fullStr |
Drug–laboratory interaction between beta-lactam antibiotics and the galactomannan antigen test used to detect mould infections |
title_full_unstemmed |
Drug–laboratory interaction between beta-lactam antibiotics and the galactomannan antigen test used to detect mould infections |
title_sort |
drug–laboratory interaction between beta-lactam antibiotics and the galactomannan antigen test used to detect mould infections |
publisher |
Elsevier |
series |
Brazilian Journal of Infectious Diseases |
issn |
1413-8670 |
publishDate |
2014-09-01 |
description |
Several studies have demonstrated that piperacillin/tazobactam produces a false-positive result for the galactomannan antigen test. However, the most recent literature has demonstrated that this interaction is no longer a concern. There is little information regarding the drug–laboratory interaction with the generics of piperacillin/tazobactam or other broad-spectrum beta-lactams, such as ceftaroline, doripenem, imipenem/cilastatin, and meropenem. The purpose of this study was to determine if a drug–laboratory interaction exists with these antibiotics. Tests showed that one lot of imipenem/cilastatin by Hospira Healthcare India Private Limited produced a false-positive result for the galactomannan antigen test. All other medications tested, including piperacillin/tazobactam from seven manufacturers and imipenem/cilastatin by Hospira Inc., did not produce positive results. Since the reason for this drug–laboratory interaction with imipenem/cilastatin is unknown, more studies are needed to further investigate this interaction. Providers also should be educated of these findings: no drug–laboratory interaction with piperacillin/tazobactam and a possible drug–laboratory interaction with imipenem/cilastatin (Hospira Healthcare India Private Limited). Keywords: Piperacillin–tazobactam, Galactomannan, Beta-lactams, Drug interaction |
url |
http://www.sciencedirect.com/science/article/pii/S1413867014000981 |
work_keys_str_mv |
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