The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter

In recent years, major advances in research and experimental approaches have significantly increased our knowledge on the role of the HIV-1 capsid in the virus life cycle, from reverse transcription to integration and gene expression. This makes the capsid protein a good pharmacological target to in...

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Main Authors:	Nawal AlBurtamani, Alwin Paul, Ariberto Fassati
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Series:	Viruses
Subjects:	HIV-1 capsid reverse transcription nuclear entry integration drugs
Online Access:	https://www.mdpi.com/1999-4915/13/6/1161

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spelling	doaj-62d71654e1724df8b68db353ed8a77d22021-07-01T00:25:50ZengMDPI AGViruses1999-49152021-06-01131161116110.3390/v13061161The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the MatterNawal AlBurtamani0Alwin Paul1Ariberto Fassati2Division of Infection & Immunity, Institute of Immunity and Transplantation, University College London, London WC1E 6JF, UKDivision of Infection & Immunity, Institute of Immunity and Transplantation, University College London, London WC1E 6JF, UKDivision of Infection & Immunity, Institute of Immunity and Transplantation, University College London, London WC1E 6JF, UKIn recent years, major advances in research and experimental approaches have significantly increased our knowledge on the role of the HIV-1 capsid in the virus life cycle, from reverse transcription to integration and gene expression. This makes the capsid protein a good pharmacological target to inhibit HIV-1 replication. This review covers our current understanding of the role of the viral capsid in the HIV-1 life cycle and its interaction with different host factors that enable reverse transcription, trafficking towards the nucleus, nuclear import and integration into host chromosomes. It also describes different promising small molecules, some of them in clinical trials, as potential targets for HIV-1 therapy.https://www.mdpi.com/1999-4915/13/6/1161HIV-1capsidreverse transcriptionnuclear entryintegrationdrugs
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nawal AlBurtamani Alwin Paul Ariberto Fassati
spellingShingle	Nawal AlBurtamani Alwin Paul Ariberto Fassati The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter Viruses HIV-1 capsid reverse transcription nuclear entry integration drugs
author_facet	Nawal AlBurtamani Alwin Paul Ariberto Fassati
author_sort	Nawal AlBurtamani
title	The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter
title_short	The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter
title_full	The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter
title_fullStr	The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter
title_full_unstemmed	The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter
title_sort	role of capsid in the early steps of hiv-1 infection: new insights into the core of the matter
publisher	MDPI AG
series	Viruses
issn	1999-4915
publishDate	2021-06-01
description	In recent years, major advances in research and experimental approaches have significantly increased our knowledge on the role of the HIV-1 capsid in the virus life cycle, from reverse transcription to integration and gene expression. This makes the capsid protein a good pharmacological target to inhibit HIV-1 replication. This review covers our current understanding of the role of the viral capsid in the HIV-1 life cycle and its interaction with different host factors that enable reverse transcription, trafficking towards the nucleus, nuclear import and integration into host chromosomes. It also describes different promising small molecules, some of them in clinical trials, as potential targets for HIV-1 therapy.
topic	HIV-1 capsid reverse transcription nuclear entry integration drugs
url	https://www.mdpi.com/1999-4915/13/6/1161
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The Role of Capsid in the Early Steps of HIV-1 Infection: New Insights into the Core of the Matter

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