Microstructural White Matter Characteristics in Parkinson's Disease With Depression: A Diffusion Tensor Imaging Replication Study
Background: Clarifying the neuropathology of depression as a symptom of Parkinson's disease (PD) has been the goal of recent neuroimaging studies; however, results have been conflicting and lack replication. The purpose of the current study was to replicate recent methods that have used diffusi...
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doaj-62da4fb249874bce81b823a7f31da21b2020-11-25T00:10:08ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-08-011010.3389/fneur.2019.00884474176Microstructural White Matter Characteristics in Parkinson's Disease With Depression: A Diffusion Tensor Imaging Replication StudyColleen Lacey0Lisa Ohlhauser1Jodie Reanna Gawryluk2Jodie Reanna Gawryluk3Jodie Reanna Gawryluk4Psychology Department, University of Victoria, Victoria, BC, CanadaPsychology Department, University of Victoria, Victoria, BC, CanadaPsychology Department, University of Victoria, Victoria, BC, CanadaThe Institute on Aging and Lifelong Health, University of Victoria, Victoria, BC, CanadaThe Division of Medical Sciences, University of Victoria, Victoria, BC, CanadaBackground: Clarifying the neuropathology of depression as a symptom of Parkinson's disease (PD) has been the goal of recent neuroimaging studies; however, results have been conflicting and lack replication. The purpose of the current study was to replicate recent methods that have used diffusion tensor imaging (DTI) to compare individuals with PD with and without depression and to extend previous findings to allow for a better understanding of the results.Methods: Thirty-seven participants with de novo PD were retrieved from the Parkinson's Progression Marker's Initiative (PPMI) and were separated into a depressed PD group (dPD) or a non-depressed PD group (ndPD). Groups were determined based on scores on the Geriatric Depression Scale Short Form (GDS-15). Initially, a replicated cut off score of ≥ 5 for dPD and <5 for ndPD was applied. To better understand the results, we secondarily applied a more extreme group analysis with ≥ 9 for dPD and 0 for ndPD. White matter integrity between groups was compared between groups using tract-based spatial statistics.Results and Conclusion: The current study did not reveal significant differences in white matter microstructure between dPD and ndPD groups at the whole brain level or in specific regions of interest. The extreme group results were consistent. These findings did not replicate previous work that found reduced white matter integrity in limbic prefrontal regions in dPD relative to ndPD. The current study highlights the need for more replications of neuroimaging research.https://www.frontiersin.org/article/10.3389/fneur.2019.00884/fullParkinson's diseasedepressiondiffusion tensor imagingwhite matterreplication |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Colleen Lacey Lisa Ohlhauser Jodie Reanna Gawryluk Jodie Reanna Gawryluk Jodie Reanna Gawryluk |
spellingShingle |
Colleen Lacey Lisa Ohlhauser Jodie Reanna Gawryluk Jodie Reanna Gawryluk Jodie Reanna Gawryluk Microstructural White Matter Characteristics in Parkinson's Disease With Depression: A Diffusion Tensor Imaging Replication Study Frontiers in Neurology Parkinson's disease depression diffusion tensor imaging white matter replication |
author_facet |
Colleen Lacey Lisa Ohlhauser Jodie Reanna Gawryluk Jodie Reanna Gawryluk Jodie Reanna Gawryluk |
author_sort |
Colleen Lacey |
title |
Microstructural White Matter Characteristics in Parkinson's Disease With Depression: A Diffusion Tensor Imaging Replication Study |
title_short |
Microstructural White Matter Characteristics in Parkinson's Disease With Depression: A Diffusion Tensor Imaging Replication Study |
title_full |
Microstructural White Matter Characteristics in Parkinson's Disease With Depression: A Diffusion Tensor Imaging Replication Study |
title_fullStr |
Microstructural White Matter Characteristics in Parkinson's Disease With Depression: A Diffusion Tensor Imaging Replication Study |
title_full_unstemmed |
Microstructural White Matter Characteristics in Parkinson's Disease With Depression: A Diffusion Tensor Imaging Replication Study |
title_sort |
microstructural white matter characteristics in parkinson's disease with depression: a diffusion tensor imaging replication study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2019-08-01 |
description |
Background: Clarifying the neuropathology of depression as a symptom of Parkinson's disease (PD) has been the goal of recent neuroimaging studies; however, results have been conflicting and lack replication. The purpose of the current study was to replicate recent methods that have used diffusion tensor imaging (DTI) to compare individuals with PD with and without depression and to extend previous findings to allow for a better understanding of the results.Methods: Thirty-seven participants with de novo PD were retrieved from the Parkinson's Progression Marker's Initiative (PPMI) and were separated into a depressed PD group (dPD) or a non-depressed PD group (ndPD). Groups were determined based on scores on the Geriatric Depression Scale Short Form (GDS-15). Initially, a replicated cut off score of ≥ 5 for dPD and <5 for ndPD was applied. To better understand the results, we secondarily applied a more extreme group analysis with ≥ 9 for dPD and 0 for ndPD. White matter integrity between groups was compared between groups using tract-based spatial statistics.Results and Conclusion: The current study did not reveal significant differences in white matter microstructure between dPD and ndPD groups at the whole brain level or in specific regions of interest. The extreme group results were consistent. These findings did not replicate previous work that found reduced white matter integrity in limbic prefrontal regions in dPD relative to ndPD. The current study highlights the need for more replications of neuroimaging research. |
topic |
Parkinson's disease depression diffusion tensor imaging white matter replication |
url |
https://www.frontiersin.org/article/10.3389/fneur.2019.00884/full |
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