An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangement
Rearrangements involving interferon regulatory factor 4 (IRF4) gene has been recently described in a subtype of diffuse large B-cell lymphoma (DLBCL). They occur in a typical clinical setting of a pediatric age group, predominantly with tonsillar mass, usually as a low-stage disease and with good re...
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Wolters Kluwer Medknow Publications
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doaj-62e85a64336d42ce8a0d472880c533dd2020-11-25T00:31:55ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292018-01-0161227127410.4103/IJPM.IJPM_194_17An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangementAnuj VermaSridhar EpariSumeet GujralTanuja ShetRearrangements involving interferon regulatory factor 4 (IRF4) gene has been recently described in a subtype of diffuse large B-cell lymphoma (DLBCL). They occur in a typical clinical setting of a pediatric age group, predominantly with tonsillar mass, usually as a low-stage disease and with good response to chemotherapy. Histomorphologically, they show nodular/follicular architecture with diffuse strong immunopositivity for multiple myeloma oncogene 1. Here, the authors describe one such unusual case of large B-cell lymphoma with IRF4 gene rearrangement in a young child with the unusual location of inguinal region and detailed pathological (histological, immunohistochemical, and molecular) findings.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=2;spage=271;epage=274;aulast=VermaDiffusefollicularinterferon regulatory factor 4lymphomamultiple myeloma oncogene 1pediatric |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anuj Verma Sridhar Epari Sumeet Gujral Tanuja Shet |
spellingShingle |
Anuj Verma Sridhar Epari Sumeet Gujral Tanuja Shet An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangement Indian Journal of Pathology and Microbiology Diffuse follicular interferon regulatory factor 4 lymphoma multiple myeloma oncogene 1 pediatric |
author_facet |
Anuj Verma Sridhar Epari Sumeet Gujral Tanuja Shet |
author_sort |
Anuj Verma |
title |
An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangement |
title_short |
An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangement |
title_full |
An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangement |
title_fullStr |
An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangement |
title_full_unstemmed |
An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangement |
title_sort |
unusual presentation of large b-cell lymphoma with interferon regulatory factor 4 gene rearrangement |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Pathology and Microbiology |
issn |
0377-4929 |
publishDate |
2018-01-01 |
description |
Rearrangements involving interferon regulatory factor 4 (IRF4) gene has been recently described in a subtype of diffuse large B-cell lymphoma (DLBCL). They occur in a typical clinical setting of a pediatric age group, predominantly with tonsillar mass, usually as a low-stage disease and with good response to chemotherapy. Histomorphologically, they show nodular/follicular architecture with diffuse strong immunopositivity for multiple myeloma oncogene 1. Here, the authors describe one such unusual case of large B-cell lymphoma with IRF4 gene rearrangement in a young child with the unusual location of inguinal region and detailed pathological (histological, immunohistochemical, and molecular) findings. |
topic |
Diffuse follicular interferon regulatory factor 4 lymphoma multiple myeloma oncogene 1 pediatric |
url |
http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=2;spage=271;epage=274;aulast=Verma |
work_keys_str_mv |
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1725321804119015424 |