An unusual presentation of large B-cell lymphoma with interferon regulatory factor 4 gene rearrangement

• Main Authors: Anuj Verma, Sridhar Epari, Sumeet Gujral, Tanuja Shet
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018-01-01
• Series: Indian Journal of Pathology and Microbiology
• Subjects: Diffuse; follicular; interferon regulatory factor 4; lymphoma; multiple myeloma oncogene 1; pediatric
• Online Access: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=2;spage=271;epage=274;aulast=Verma

Rearrangements involving interferon regulatory factor 4 (IRF4) gene has been recently described in a subtype of diffuse large B-cell lymphoma (DLBCL). They occur in a typical clinical setting of a pediatric age group, predominantly with tonsillar mass, usually as a low-stage disease and with good response to chemotherapy. Histomorphologically, they show nodular/follicular architecture with diffuse strong immunopositivity for multiple myeloma oncogene 1. Here, the authors describe one such unusual case of large B-cell lymphoma with IRF4 gene rearrangement in a young child with the unusual location of inguinal region and detailed pathological (histological, immunohistochemical, and molecular) findings.