Similar or different? The role of the ventrolateral prefrontal cortex in similarity detection.
Patients with frontal lobe syndrome can exhibit two types of abnormal behaviour when asked to place a banana and an orange in a single category: some patients categorize them at a concrete level (e.g., "both have peel"), while others continue to look for differences between these objects (...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3316621?pdf=render |
id |
doaj-62ebf58641734283a01f16dbaef6141a |
---|---|
record_format |
Article |
spelling |
doaj-62ebf58641734283a01f16dbaef6141a2020-11-25T01:53:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0173e3416410.1371/journal.pone.0034164Similar or different? The role of the ventrolateral prefrontal cortex in similarity detection.Béatrice GarcinEmmanuelle VolleBruno DuboisRichard LevyPatients with frontal lobe syndrome can exhibit two types of abnormal behaviour when asked to place a banana and an orange in a single category: some patients categorize them at a concrete level (e.g., "both have peel"), while others continue to look for differences between these objects (e.g., "one is yellow, the other is orange"). These observations raise the question of whether abstraction and similarity detection are distinct processes involved in abstract categorization, and that depend on separate areas of the prefrontal cortex (PFC). We designed an original experimental paradigm for a functional magnetic resonance imaging (fMRI) study involving healthy subjects, confirming the existence of two distinct processes relying on different prefrontal areas, and thus explaining the behavioural dissociation in frontal lesion patients. We showed that: 1) Similarity detection involves the anterior ventrolateral PFC bilaterally with a right-left asymmetry: the right anterior ventrolateral PFC is only engaged in detecting physical similarities; 2) Abstraction per se activates the left dorsolateral PFC.http://europepmc.org/articles/PMC3316621?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Béatrice Garcin Emmanuelle Volle Bruno Dubois Richard Levy |
spellingShingle |
Béatrice Garcin Emmanuelle Volle Bruno Dubois Richard Levy Similar or different? The role of the ventrolateral prefrontal cortex in similarity detection. PLoS ONE |
author_facet |
Béatrice Garcin Emmanuelle Volle Bruno Dubois Richard Levy |
author_sort |
Béatrice Garcin |
title |
Similar or different? The role of the ventrolateral prefrontal cortex in similarity detection. |
title_short |
Similar or different? The role of the ventrolateral prefrontal cortex in similarity detection. |
title_full |
Similar or different? The role of the ventrolateral prefrontal cortex in similarity detection. |
title_fullStr |
Similar or different? The role of the ventrolateral prefrontal cortex in similarity detection. |
title_full_unstemmed |
Similar or different? The role of the ventrolateral prefrontal cortex in similarity detection. |
title_sort |
similar or different? the role of the ventrolateral prefrontal cortex in similarity detection. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
Patients with frontal lobe syndrome can exhibit two types of abnormal behaviour when asked to place a banana and an orange in a single category: some patients categorize them at a concrete level (e.g., "both have peel"), while others continue to look for differences between these objects (e.g., "one is yellow, the other is orange"). These observations raise the question of whether abstraction and similarity detection are distinct processes involved in abstract categorization, and that depend on separate areas of the prefrontal cortex (PFC). We designed an original experimental paradigm for a functional magnetic resonance imaging (fMRI) study involving healthy subjects, confirming the existence of two distinct processes relying on different prefrontal areas, and thus explaining the behavioural dissociation in frontal lesion patients. We showed that: 1) Similarity detection involves the anterior ventrolateral PFC bilaterally with a right-left asymmetry: the right anterior ventrolateral PFC is only engaged in detecting physical similarities; 2) Abstraction per se activates the left dorsolateral PFC. |
url |
http://europepmc.org/articles/PMC3316621?pdf=render |
work_keys_str_mv |
AT beatricegarcin similarordifferenttheroleoftheventrolateralprefrontalcortexinsimilaritydetection AT emmanuellevolle similarordifferenttheroleoftheventrolateralprefrontalcortexinsimilaritydetection AT brunodubois similarordifferenttheroleoftheventrolateralprefrontalcortexinsimilaritydetection AT richardlevy similarordifferenttheroleoftheventrolateralprefrontalcortexinsimilaritydetection |
_version_ |
1724990819778166784 |