Ginkgo biloba Extract for Patients with Early Diabetic Nephropathy: A Systematic Review
Objectives. To evaluate the effectiveness and safety of a Ginkgo biloba extract for patients with early diabetic nephropathy. Methods. Randomised controlled trials (RCTs) conducted on adults with early diabetic nephropathy which used Gingko biloba extract were included. The major databases were sear...
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doaj-62ee38e3c8be46a595dc350041b9e4242020-11-24T22:59:52ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882013-01-01201310.1155/2013/689142689142Ginkgo biloba Extract for Patients with Early Diabetic Nephropathy: A Systematic ReviewLei Zhang0Wei Mao1Xinfeng Guo2Yifan Wu3Chuang Li4Zhaoyu Lu5Guobin Su6Xiaoyan Li7Zhuangzhu Liu8Rong Guo9Xina Jie10Zehuai Wen11Xusheng Liu12Nephropathy Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, ChinaNephropathy Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, ChinaKey Unit of Methodology in Clinical Research, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, ChinaNephropathy Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, ChinaNephropathy Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, ChinaNephropathy Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, ChinaNephropathy Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, ChinaKey Unit of Methodology in Clinical Research, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, ChinaThe Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaThe Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaThe Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou 510405, ChinaKey Unit of Methodology in Clinical Research, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, ChinaNephropathy Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, ChinaObjectives. To evaluate the effectiveness and safety of a Ginkgo biloba extract for patients with early diabetic nephropathy. Methods. Randomised controlled trials (RCTs) conducted on adults with early diabetic nephropathy which used Gingko biloba extract were included. The major databases were searched, and manufacturers of Gingko biloba products were contacted for information on any published or unpublished studies. Two authors independently extracted the data from the included studies. Data analysis was conducted using Review Manager 5.0 software. Results. Sixteen RCTs were included. Ginkgo biloba extract decreased the urinary albumin excretion rate (UAER), fasting blood glucose (FBG), serum creatinine (SCR), and blood urea nitrogen (BUN). The extract also improved hemorheology. The methodological quality in the included studies was low. The explicit generation of the allocation sequence was described in only 6 trials. None of the included trials were confirmed to use blinding. Three studies had observed adverse events. One study using angiotensin-converting enzyme inhibitor (ACEi) reported mild cough in both groups. No serious adverse effects were reported. Conclusions. Gingko biloba extract is a valuable drug which has prospect in treating early diabetic nephropathy, especially with high UAER baseline level. The safety for early diabetic nephropathy is uncertain. Long-term, double-blinded RCTs with large sample sizes are still needed to provide stronger evidence.http://dx.doi.org/10.1155/2013/689142 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lei Zhang Wei Mao Xinfeng Guo Yifan Wu Chuang Li Zhaoyu Lu Guobin Su Xiaoyan Li Zhuangzhu Liu Rong Guo Xina Jie Zehuai Wen Xusheng Liu |
spellingShingle |
Lei Zhang Wei Mao Xinfeng Guo Yifan Wu Chuang Li Zhaoyu Lu Guobin Su Xiaoyan Li Zhuangzhu Liu Rong Guo Xina Jie Zehuai Wen Xusheng Liu Ginkgo biloba Extract for Patients with Early Diabetic Nephropathy: A Systematic Review Evidence-Based Complementary and Alternative Medicine |
author_facet |
Lei Zhang Wei Mao Xinfeng Guo Yifan Wu Chuang Li Zhaoyu Lu Guobin Su Xiaoyan Li Zhuangzhu Liu Rong Guo Xina Jie Zehuai Wen Xusheng Liu |
author_sort |
Lei Zhang |
title |
Ginkgo biloba Extract for Patients with Early Diabetic Nephropathy: A Systematic Review |
title_short |
Ginkgo biloba Extract for Patients with Early Diabetic Nephropathy: A Systematic Review |
title_full |
Ginkgo biloba Extract for Patients with Early Diabetic Nephropathy: A Systematic Review |
title_fullStr |
Ginkgo biloba Extract for Patients with Early Diabetic Nephropathy: A Systematic Review |
title_full_unstemmed |
Ginkgo biloba Extract for Patients with Early Diabetic Nephropathy: A Systematic Review |
title_sort |
ginkgo biloba extract for patients with early diabetic nephropathy: a systematic review |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2013-01-01 |
description |
Objectives. To evaluate the effectiveness and safety of a Ginkgo biloba extract for patients with early diabetic nephropathy. Methods. Randomised controlled trials (RCTs) conducted on adults with early diabetic nephropathy which used Gingko biloba extract were included. The major databases were searched, and manufacturers of Gingko biloba products were contacted for information on any published or unpublished studies. Two authors independently extracted the data from the included studies. Data analysis was conducted using Review Manager 5.0 software. Results. Sixteen RCTs were included. Ginkgo biloba extract decreased the urinary albumin excretion rate (UAER), fasting blood glucose (FBG), serum creatinine (SCR), and blood urea nitrogen (BUN). The extract also improved hemorheology. The methodological quality in the included studies was low. The explicit generation of the allocation sequence was described in only 6 trials. None of the included trials were confirmed to use blinding. Three studies had observed adverse events. One study using angiotensin-converting enzyme inhibitor (ACEi) reported mild cough in both groups. No serious adverse effects were reported. Conclusions. Gingko biloba extract is a valuable drug which has prospect in treating early diabetic nephropathy, especially with high UAER baseline level. The safety for early diabetic nephropathy is uncertain. Long-term, double-blinded RCTs with large sample sizes are still needed to provide stronger evidence. |
url |
http://dx.doi.org/10.1155/2013/689142 |
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