Epstein-Barr virus (EBV) infection in Chinese children: a retrospective study of age-specific prevalence.
BACKGROUND: Epstein-Barr Virus (EBV) is a globally prevalent herpesvirus associated with infectious mononucleosis and many malignancies. The survey on EBV prevalence appears to be important to study EBV-related diseases and determine when to administer prophylactic vaccine. The purpose of this retro...
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doaj-62feb3c02ce44e96a1e243d953161c6c2020-11-25T01:34:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e9985710.1371/journal.pone.0099857Epstein-Barr virus (EBV) infection in Chinese children: a retrospective study of age-specific prevalence.Geng XiongBo ZhangMu-yun HuangHufeng ZhouLi-zhen ChenQi-sheng FengXi LuoHui-jia LinYi-xin ZengBACKGROUND: Epstein-Barr Virus (EBV) is a globally prevalent herpesvirus associated with infectious mononucleosis and many malignancies. The survey on EBV prevalence appears to be important to study EBV-related diseases and determine when to administer prophylactic vaccine. The purpose of this retrospective study was to collect baseline information about the prevalence of EBV infection in Chinese children. METHODOLOGY/PRINCIPAL FINDING: We collected 1778 serum samples from healthy children aged 0 to 10, who were enrolled in conventional health and nutrition examinations without any EBV-related symptom in 2012 and 2013 in North China (n = 973) and South China (n = 805). We detected four EBV-specific antibodies, i.e., anti-VCA-IgG and IgM, anti-EBNA-IgG and anti-EA-IgG, by ELISA, representing all of the phases of EBV infection. The overall EBV seroprevalence in samples from North and South China were 80.78% and 79.38% respectively. The EBV seropositivity rates dropped slightly at age 2, and then increased gradually with age. The seroprevalence became stabilized at over 90% after age 8. In this study, the seroprevalence trends between North and South China showed no difference (P>0.05), and the trends of average antibody concentrations were similar as well (P>0.05). CONCLUSIONS/SIGNIFICANCE: EBV seroprevalence became more than 50% before age 3 in Chinese children, and exceed 90% after age 8. This study can be helpful to study the relationship between EBV and EBV-associated diseases, and supportive to EBV vaccine development and implementation.http://europepmc.org/articles/PMC4051769?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Geng Xiong Bo Zhang Mu-yun Huang Hufeng Zhou Li-zhen Chen Qi-sheng Feng Xi Luo Hui-jia Lin Yi-xin Zeng |
spellingShingle |
Geng Xiong Bo Zhang Mu-yun Huang Hufeng Zhou Li-zhen Chen Qi-sheng Feng Xi Luo Hui-jia Lin Yi-xin Zeng Epstein-Barr virus (EBV) infection in Chinese children: a retrospective study of age-specific prevalence. PLoS ONE |
author_facet |
Geng Xiong Bo Zhang Mu-yun Huang Hufeng Zhou Li-zhen Chen Qi-sheng Feng Xi Luo Hui-jia Lin Yi-xin Zeng |
author_sort |
Geng Xiong |
title |
Epstein-Barr virus (EBV) infection in Chinese children: a retrospective study of age-specific prevalence. |
title_short |
Epstein-Barr virus (EBV) infection in Chinese children: a retrospective study of age-specific prevalence. |
title_full |
Epstein-Barr virus (EBV) infection in Chinese children: a retrospective study of age-specific prevalence. |
title_fullStr |
Epstein-Barr virus (EBV) infection in Chinese children: a retrospective study of age-specific prevalence. |
title_full_unstemmed |
Epstein-Barr virus (EBV) infection in Chinese children: a retrospective study of age-specific prevalence. |
title_sort |
epstein-barr virus (ebv) infection in chinese children: a retrospective study of age-specific prevalence. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
BACKGROUND: Epstein-Barr Virus (EBV) is a globally prevalent herpesvirus associated with infectious mononucleosis and many malignancies. The survey on EBV prevalence appears to be important to study EBV-related diseases and determine when to administer prophylactic vaccine. The purpose of this retrospective study was to collect baseline information about the prevalence of EBV infection in Chinese children. METHODOLOGY/PRINCIPAL FINDING: We collected 1778 serum samples from healthy children aged 0 to 10, who were enrolled in conventional health and nutrition examinations without any EBV-related symptom in 2012 and 2013 in North China (n = 973) and South China (n = 805). We detected four EBV-specific antibodies, i.e., anti-VCA-IgG and IgM, anti-EBNA-IgG and anti-EA-IgG, by ELISA, representing all of the phases of EBV infection. The overall EBV seroprevalence in samples from North and South China were 80.78% and 79.38% respectively. The EBV seropositivity rates dropped slightly at age 2, and then increased gradually with age. The seroprevalence became stabilized at over 90% after age 8. In this study, the seroprevalence trends between North and South China showed no difference (P>0.05), and the trends of average antibody concentrations were similar as well (P>0.05). CONCLUSIONS/SIGNIFICANCE: EBV seroprevalence became more than 50% before age 3 in Chinese children, and exceed 90% after age 8. This study can be helpful to study the relationship between EBV and EBV-associated diseases, and supportive to EBV vaccine development and implementation. |
url |
http://europepmc.org/articles/PMC4051769?pdf=render |
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