Shallow whole-genome sequencing of plasma cell-free DNA accurately differentiates small from non-small cell lung carcinoma

Shallow whole-genome sequencing of plasma cell-free DNA accurately differentiates small from non-small cell lung carcinoma

Abstract Background Accurate lung cancer classification is crucial to guide therapeutic decisions. However, histological subtyping by pathologists requires tumor tissue—a necessity that is often intrinsically associated with procedural difficulties. The analysis of circulating tumor DNA present in m...

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Bibliographic Details
Main Authors: Lennart Raman, Malaïka Van der Linden, Kim Van der Eecken, Karim Vermaelen, Ingel Demedts, Veerle Surmont, Ulrike Himpe, Franceska Dedeurwaerdere, Liesbeth Ferdinande, Yolande Lievens, Kathleen Claes, Björn Menten, Jo Van Dorpe
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Genome Medicine
Subjects:
Lung cancer
Liquid biopsy
Cell-free DNA
Shallow whole-genome sequencing
Copy number alterations
Histological classification
Online Access:http://link.springer.com/article/10.1186/s13073-020-00735-4

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