Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases

Oxidative stress is involved in several diseases and is a target for intervention. Here, the authors report on the synthesis of ultrasmall copper-based nanozymes as reactive oxygen species scavengers and demonstrate improved treatment outcomes in acute liver and kidney injury and wound healing in vi...

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Main Authors:	Tengfei Liu, Bowen Xiao, Fei Xiang, Jianglin Tan, Zhuo Chen, Xiaorong Zhang, Chengzhou Wu, Zhengwei Mao, Gaoxing Luo, Xiaoyuan Chen, Jun Deng
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16544-7

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spelling	doaj-6305fe0950ed4c5d993b3d53e1caef4c2021-06-06T11:15:19ZengNature Publishing GroupNature Communications2041-17232020-06-0111111610.1038/s41467-020-16544-7Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseasesTengfei Liu0Bowen Xiao1Fei Xiang2Jianglin Tan3Zhuo Chen4Xiaorong Zhang5Chengzhou Wu6Zhengwei Mao7Gaoxing Luo8Xiaoyuan Chen9Jun Deng10Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Third Military Medical University (Army Medical University)Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Third Military Medical University (Army Medical University)Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Third Military Medical University (Army Medical University)Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Third Military Medical University (Army Medical University)Department of Endocrinology, Southwest Hospital, Third Military Medical University (Army Medical University)Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Third Military Medical University (Army Medical University)Department of Respiratory Care, Wuxi County People’s HospitalInstitute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Third Military Medical University (Army Medical University)Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Third Military Medical University (Army Medical University)Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthInstitute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Third Military Medical University (Army Medical University)Oxidative stress is involved in several diseases and is a target for intervention. Here, the authors report on the synthesis of ultrasmall copper-based nanozymes as reactive oxygen species scavengers and demonstrate improved treatment outcomes in acute liver and kidney injury and wound healing in vivo.https://doi.org/10.1038/s41467-020-16544-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tengfei Liu Bowen Xiao Fei Xiang Jianglin Tan Zhuo Chen Xiaorong Zhang Chengzhou Wu Zhengwei Mao Gaoxing Luo Xiaoyuan Chen Jun Deng
spellingShingle	Tengfei Liu Bowen Xiao Fei Xiang Jianglin Tan Zhuo Chen Xiaorong Zhang Chengzhou Wu Zhengwei Mao Gaoxing Luo Xiaoyuan Chen Jun Deng Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases Nature Communications
author_facet	Tengfei Liu Bowen Xiao Fei Xiang Jianglin Tan Zhuo Chen Xiaorong Zhang Chengzhou Wu Zhengwei Mao Gaoxing Luo Xiaoyuan Chen Jun Deng
author_sort	Tengfei Liu
title	Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
title_short	Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
title_full	Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
title_fullStr	Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
title_full_unstemmed	Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
title_sort	ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-06-01
description	Oxidative stress is involved in several diseases and is a target for intervention. Here, the authors report on the synthesis of ultrasmall copper-based nanozymes as reactive oxygen species scavengers and demonstrate improved treatment outcomes in acute liver and kidney injury and wound healing in vivo.
url	https://doi.org/10.1038/s41467-020-16544-7
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Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases

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