Negative Modulation of TRPM8 Channel Function by Protein Kinase C in Trigeminal Cold Thermoreceptor Neurons

Negative Modulation of TRPM8 Channel Function by Protein Kinase C in Trigeminal Cold Thermoreceptor Neurons

TRPM8 is the main molecular entity responsible for cold sensing. This polymodal ion channel is activated by cold, cooling compounds such as menthol, voltage, and rises in osmolality. In corneal cold thermoreceptor neurons (CTNs), TRPM8 expression determines not only their sensitivity to cold, but al...

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Bibliographic Details
Main Authors: Bastián Rivera, Matías Campos, Patricio Orio, Rodolfo Madrid, María Pertusa
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
primary sensory neurons
corneal nerve endings
cold transduction
plasma membrane
PMA
menthol
Online Access:https://www.mdpi.com/1422-0067/21/12/4420

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