Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States—A Systematic Review of fMRI Studies
Cognitive biases are an important factor contributing to the development and symptom severity of psychosis. Despite the fact that various cognitive biases are contributing to psychosis, they are rarely investigated together. In the current systematic review, we aimed at investigating specific and sh...
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doaj-630ab2b467f944dba4acda3a8375c0762021-09-26T00:28:13ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-01104126412610.3390/jcm10184126Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States—A Systematic Review of fMRI StudiesJoachim Kowalski0Adrianna Aleksandrowicz1Małgorzata Dąbkowska2Łukasz Gawęda3Experimental Psychopathology Lab, Institute of Psychology, Polish Academy of Sciences, ul. Jaracza 1, 00-378 Warsaw, PolandExperimental Psychopathology Lab, Institute of Psychology, Polish Academy of Sciences, ul. Jaracza 1, 00-378 Warsaw, PolandExperimental Psychopathology Lab, Institute of Psychology, Polish Academy of Sciences, ul. Jaracza 1, 00-378 Warsaw, PolandExperimental Psychopathology Lab, Institute of Psychology, Polish Academy of Sciences, ul. Jaracza 1, 00-378 Warsaw, PolandCognitive biases are an important factor contributing to the development and symptom severity of psychosis. Despite the fact that various cognitive biases are contributing to psychosis, they are rarely investigated together. In the current systematic review, we aimed at investigating specific and shared functional neural correlates of two important cognitive biases: aberrant salience and source monitoring. We conducted a systematic search of fMRI studies of said cognitive biases. Eight studies on aberrant salience and eleven studies on source monitoring were included in the review. We critically discussed behavioural and neuroimaging findings concerning cognitive biases. Various brain regions are associated with aberrant salience and source monitoring in individuals with schizophrenia and the risk of psychosis. The ventral striatum and insula contribute to aberrant salience. The medial prefrontal cortex, superior and middle temporal gyrus contribute to source monitoring. The anterior cingulate cortex and hippocampus contribute to both cognitive biases, constituting a neural overlap. Our review indicates that aberrant salience and source monitoring may share neural mechanisms, suggesting their joint role in producing disrupted external attributions of perceptual and cognitive experiences, thus elucidating their role in positive symptoms of psychosis. Account bridging mechanisms of these two biases is discussed. Further studies are warranted.https://www.mdpi.com/2077-0383/10/18/4126aberrant saliencesource monitoringpsychosiscognitive biasesself-disturbanceneural |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joachim Kowalski Adrianna Aleksandrowicz Małgorzata Dąbkowska Łukasz Gawęda |
spellingShingle |
Joachim Kowalski Adrianna Aleksandrowicz Małgorzata Dąbkowska Łukasz Gawęda Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States—A Systematic Review of fMRI Studies Journal of Clinical Medicine aberrant salience source monitoring psychosis cognitive biases self-disturbance neural |
author_facet |
Joachim Kowalski Adrianna Aleksandrowicz Małgorzata Dąbkowska Łukasz Gawęda |
author_sort |
Joachim Kowalski |
title |
Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States—A Systematic Review of fMRI Studies |
title_short |
Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States—A Systematic Review of fMRI Studies |
title_full |
Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States—A Systematic Review of fMRI Studies |
title_fullStr |
Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States—A Systematic Review of fMRI Studies |
title_full_unstemmed |
Neural Correlates of Aberrant Salience and Source Monitoring in Schizophrenia and At-Risk Mental States—A Systematic Review of fMRI Studies |
title_sort |
neural correlates of aberrant salience and source monitoring in schizophrenia and at-risk mental states—a systematic review of fmri studies |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-09-01 |
description |
Cognitive biases are an important factor contributing to the development and symptom severity of psychosis. Despite the fact that various cognitive biases are contributing to psychosis, they are rarely investigated together. In the current systematic review, we aimed at investigating specific and shared functional neural correlates of two important cognitive biases: aberrant salience and source monitoring. We conducted a systematic search of fMRI studies of said cognitive biases. Eight studies on aberrant salience and eleven studies on source monitoring were included in the review. We critically discussed behavioural and neuroimaging findings concerning cognitive biases. Various brain regions are associated with aberrant salience and source monitoring in individuals with schizophrenia and the risk of psychosis. The ventral striatum and insula contribute to aberrant salience. The medial prefrontal cortex, superior and middle temporal gyrus contribute to source monitoring. The anterior cingulate cortex and hippocampus contribute to both cognitive biases, constituting a neural overlap. Our review indicates that aberrant salience and source monitoring may share neural mechanisms, suggesting their joint role in producing disrupted external attributions of perceptual and cognitive experiences, thus elucidating their role in positive symptoms of psychosis. Account bridging mechanisms of these two biases is discussed. Further studies are warranted. |
topic |
aberrant salience source monitoring psychosis cognitive biases self-disturbance neural |
url |
https://www.mdpi.com/2077-0383/10/18/4126 |
work_keys_str_mv |
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