Modeling gene-environment interactions in longitudinal family studies: a comparison of methods and their application to the association between the IGF pathway and childhood obesity

Modeling gene-environment interactions in longitudinal family studies: a comparison of methods and their application to the association between the IGF pathway and childhood obesity

Abstract Background The interactive effect of the IGF pathway genes with the environment may contribute to childhood obesity. Such gene-environment interactions can take on complex forms. Detecting those relationships using longitudinal family studies requires simultaneously accounting for correlati...

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Bibliographic Details
Main Authors: Cheng Wang, Marie-Hélène Roy-Gagnon, Jean-François Lefebvre, Kelly M. Burkett, Lise Dubois
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Medical Genetics
Subjects:
Childhood obesity
Insulin-like growth factors
Twin studies
Longitudinal family studies
Gene-environment interaction
Non-linear interaction
Online Access:http://link.springer.com/article/10.1186/s12881-018-0739-x

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http://link.springer.com/article/10.1186/s12881-018-0739-x

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