Ultrasound Doppler as an Imaging Modality for Selection of Murine 4T1 Breast Tumors for Combination Radiofrequency Hyperthermia and Chemotherapy
Noninvasive radiofrequency-induced (RF) hyperthermia has been shown to increase the perfusion of chemotherapeutics and nanomaterials through cancer tissue in ectopic and orthotopic murine tumor models. Additionally, mild hyperthermia (37°C-45°C) has previously shown a synergistic anticancer effect w...
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doaj-630e13c0b79b410f804ff8317cf071c52020-11-24T22:57:52ZengElsevierTranslational Oncology1936-52332018-08-01114864872Ultrasound Doppler as an Imaging Modality for Selection of Murine 4T1 Breast Tumors for Combination Radiofrequency Hyperthermia and ChemotherapyMartyna Krzykawska-Serda0Jason Chak-Shing Ho1Matthew J. Ware2Justin J. Law3Jared M. Newton4Lam Nguyen5Mahdi Agha6Steven A. Curley7Stuart J. Corr8Baylor College of Medicine, Dept. of Surgery, Houston, TX, USA; Jagiellonian University, Dept. Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Krakow, Poland; Address all correspondence to: Martyna Krzykawska-Serda, Dept. Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Gronostajowa 7, 30-387 Krakow, Poland or Stuart J. Corr, Dept. of Surgery, Houston, TX, USA.Baylor College of Medicine, Dept. of Surgery, Houston, TX, USABaylor College of Medicine, Dept. of Surgery, Houston, TX, USABaylor College of Medicine, Dept. of Surgery, Houston, TX, USABaylor College of Medicine, Dept. of Surgery, Houston, TX, USA; Baylor College of Medicine, Interdepartmental Program in Translational Biology and Molecular Medicine, Houston, TX, USABaylor College of Medicine, Dept. of Surgery, Houston, TX, USABaylor College of Medicine, Dept. of Surgery, Houston, TX, USABaylor College of Medicine, Dept. of Surgery, Houston, TX, USA; Rice University, Dept. of Mechanical Engineering and Materials Science, Houston, TX, USABaylor College of Medicine, Dept. of Surgery, Houston, TX, USA; University of Houston, Dept. of Biomedical Engineering, Houston, TX, USA; Rice University, Dept. of Chemistry and Smalley-Curl Institute, Houston, TX, USA; Swansea University, Medical School, Swansea, Wales, UK; Address all correspondence to: Martyna Krzykawska-Serda, Dept. Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Gronostajowa 7, 30-387 Krakow, Poland or Stuart J. Corr, Dept. of Surgery, Houston, TX, USA.Noninvasive radiofrequency-induced (RF) hyperthermia has been shown to increase the perfusion of chemotherapeutics and nanomaterials through cancer tissue in ectopic and orthotopic murine tumor models. Additionally, mild hyperthermia (37°C-45°C) has previously shown a synergistic anticancer effect when used with standard-of-care chemotherapeutics such as gemcitabine and Abraxane. However, RF hyperthermia treatment schedules remain unoptimized, and the mechanisms of action of hyperthermia and how they change when treating various tumor phenotypes are poorly understood. Therefore, pretreatment screening of tumor phenotypes to identify key tumors that are predicted to respond more favorably to hyperthermia will provide useful mechanistic data and may improve therapeutic outcomes. Herein, we identify key biophysical tumor characteristics in order to predict the outcome of combinational RF and chemotherapy treatment. We demonstrate that ultrasound imaging using Doppler mode can be utilized to predict the response of combinational RF and chemotherapeutic therapy in a murine 4T1 breast cancer model.http://www.sciencedirect.com/science/article/pii/S1936523318300652 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Martyna Krzykawska-Serda Jason Chak-Shing Ho Matthew J. Ware Justin J. Law Jared M. Newton Lam Nguyen Mahdi Agha Steven A. Curley Stuart J. Corr |
spellingShingle |
Martyna Krzykawska-Serda Jason Chak-Shing Ho Matthew J. Ware Justin J. Law Jared M. Newton Lam Nguyen Mahdi Agha Steven A. Curley Stuart J. Corr Ultrasound Doppler as an Imaging Modality for Selection of Murine 4T1 Breast Tumors for Combination Radiofrequency Hyperthermia and Chemotherapy Translational Oncology |
author_facet |
Martyna Krzykawska-Serda Jason Chak-Shing Ho Matthew J. Ware Justin J. Law Jared M. Newton Lam Nguyen Mahdi Agha Steven A. Curley Stuart J. Corr |
author_sort |
Martyna Krzykawska-Serda |
title |
Ultrasound Doppler as an Imaging Modality for Selection of Murine 4T1 Breast Tumors for Combination Radiofrequency Hyperthermia and Chemotherapy |
title_short |
Ultrasound Doppler as an Imaging Modality for Selection of Murine 4T1 Breast Tumors for Combination Radiofrequency Hyperthermia and Chemotherapy |
title_full |
Ultrasound Doppler as an Imaging Modality for Selection of Murine 4T1 Breast Tumors for Combination Radiofrequency Hyperthermia and Chemotherapy |
title_fullStr |
Ultrasound Doppler as an Imaging Modality for Selection of Murine 4T1 Breast Tumors for Combination Radiofrequency Hyperthermia and Chemotherapy |
title_full_unstemmed |
Ultrasound Doppler as an Imaging Modality for Selection of Murine 4T1 Breast Tumors for Combination Radiofrequency Hyperthermia and Chemotherapy |
title_sort |
ultrasound doppler as an imaging modality for selection of murine 4t1 breast tumors for combination radiofrequency hyperthermia and chemotherapy |
publisher |
Elsevier |
series |
Translational Oncology |
issn |
1936-5233 |
publishDate |
2018-08-01 |
description |
Noninvasive radiofrequency-induced (RF) hyperthermia has been shown to increase the perfusion of chemotherapeutics and nanomaterials through cancer tissue in ectopic and orthotopic murine tumor models. Additionally, mild hyperthermia (37°C-45°C) has previously shown a synergistic anticancer effect when used with standard-of-care chemotherapeutics such as gemcitabine and Abraxane. However, RF hyperthermia treatment schedules remain unoptimized, and the mechanisms of action of hyperthermia and how they change when treating various tumor phenotypes are poorly understood. Therefore, pretreatment screening of tumor phenotypes to identify key tumors that are predicted to respond more favorably to hyperthermia will provide useful mechanistic data and may improve therapeutic outcomes. Herein, we identify key biophysical tumor characteristics in order to predict the outcome of combinational RF and chemotherapy treatment. We demonstrate that ultrasound imaging using Doppler mode can be utilized to predict the response of combinational RF and chemotherapeutic therapy in a murine 4T1 breast cancer model. |
url |
http://www.sciencedirect.com/science/article/pii/S1936523318300652 |
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