Changes in bioactive lipid mediators in response to short-term exposure to ambient air particulate matter: A targeted lipidomic analysis of oxylipin signaling pathways
Background: Exposure to ambient air particulate matter (PM) is a risk factor for cardiometabolic diseases. The knowledge of the underlying mechanisms is still evolving, but systemic inflammation and oxidative stress are central to the ability of PM to induce cardiometabolic effects. Oxylipins derive...
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Elsevier
2021-02-01
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Series: | Environment International |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412020322698 |
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doaj-63144eba2c5b492e9b33dd8977ca0113 |
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record_format |
Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Teng Wang Yiqun Han Haonan Li Yanwen Wang Tao Xue Xi Chen Wu Chen Yunfei Fan Xinghua Qiu Jicheng Gong Yifan Xu Junxia Wang Weiju Li Tong Zhu |
spellingShingle |
Teng Wang Yiqun Han Haonan Li Yanwen Wang Tao Xue Xi Chen Wu Chen Yunfei Fan Xinghua Qiu Jicheng Gong Yifan Xu Junxia Wang Weiju Li Tong Zhu Changes in bioactive lipid mediators in response to short-term exposure to ambient air particulate matter: A targeted lipidomic analysis of oxylipin signaling pathways Environment International Particulate matter PUFAs Oxylipins Lipoxygenase Cytochrome P450 Cyclooxygenase |
author_facet |
Teng Wang Yiqun Han Haonan Li Yanwen Wang Tao Xue Xi Chen Wu Chen Yunfei Fan Xinghua Qiu Jicheng Gong Yifan Xu Junxia Wang Weiju Li Tong Zhu |
author_sort |
Teng Wang |
title |
Changes in bioactive lipid mediators in response to short-term exposure to ambient air particulate matter: A targeted lipidomic analysis of oxylipin signaling pathways |
title_short |
Changes in bioactive lipid mediators in response to short-term exposure to ambient air particulate matter: A targeted lipidomic analysis of oxylipin signaling pathways |
title_full |
Changes in bioactive lipid mediators in response to short-term exposure to ambient air particulate matter: A targeted lipidomic analysis of oxylipin signaling pathways |
title_fullStr |
Changes in bioactive lipid mediators in response to short-term exposure to ambient air particulate matter: A targeted lipidomic analysis of oxylipin signaling pathways |
title_full_unstemmed |
Changes in bioactive lipid mediators in response to short-term exposure to ambient air particulate matter: A targeted lipidomic analysis of oxylipin signaling pathways |
title_sort |
changes in bioactive lipid mediators in response to short-term exposure to ambient air particulate matter: a targeted lipidomic analysis of oxylipin signaling pathways |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2021-02-01 |
description |
Background: Exposure to ambient air particulate matter (PM) is a risk factor for cardiometabolic diseases. The knowledge of the underlying mechanisms is still evolving, but systemic inflammation and oxidative stress are central to the ability of PM to induce cardiometabolic effects. Oxylipins derived from polyunsaturated fatty acids (PUFAs) are bioactive lipid mediators that have fundamental roles in the signaling of inflammatory events. However, the associations between oxylipins and short-term exposure to PM in humans are unknown. Methods: Using targeted lipidomic analyses, we measured 16 oxylipins derived from lipoxygenase (LOX), cytochrome P450 (CYP), and cyclooxygenase (COX) pathways and their parent PUFAs in serum samples of 110 adults enrolled in a panel study in Beijing, China. Each participant completed 2–7 clinical visits from 2013 to 2015. PM with aerodynamic diameter ≤ 2.5 μm (PM2.5) and ≤ 0.1 μm (ultrafine particles, UFPs) were continuously monitored at a station. Linear mixed-effects models were applied to examine the associations between changes in lipid mediators and exposure to ambient PM during the preceding 1 to 3 days before the clinical visit. Results: Serum concentrations of PUFAs, including omega-6 arachidonic acid (ARA) and omega-3 eicosapentaenoic acid (EPA), were significantly increased in association with interquartile range (IQR) increases in PM with different exposure windows (i.e., 1–3 days). Regarding oxylipins, significant PM-associated changes included increases in LOX-derived leukotriene B4 (LTB4), 12(S)-, 15(S)-hydroxyeicosatetraenoic acid (HETE), 12-hydroxyeicosapentaenoic acid (HEPE), and 17-hydroxydocosahexaenoic acid (HDHA); an increase in CYP-derived 5,6-dihydroxyeicosatrienoic acid (DHET); and a decrease in COX-derived prostaglandin E2. Conclusions: Short-term exposure to PM was associated with PUFAs and oxylipins derived from LOX, CYP, and COX pathways in humans. Our findings provide mechanistic insight suggesting bioactive oxylipins might be used as biomarkers and have important implications as mediators of PM-associated systemic cardiometabolic effects. |
topic |
Particulate matter PUFAs Oxylipins Lipoxygenase Cytochrome P450 Cyclooxygenase |
url |
http://www.sciencedirect.com/science/article/pii/S0160412020322698 |
work_keys_str_mv |
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doaj-63144eba2c5b492e9b33dd8977ca01132021-01-20T04:10:27ZengElsevierEnvironment International0160-41202021-02-01147106314Changes in bioactive lipid mediators in response to short-term exposure to ambient air particulate matter: A targeted lipidomic analysis of oxylipin signaling pathwaysTeng Wang0Yiqun Han1Haonan Li2Yanwen Wang3Tao Xue4Xi Chen5Wu Chen6Yunfei Fan7Xinghua Qiu8Jicheng Gong9Yifan Xu10Junxia Wang11Weiju Li12Tong Zhu13BIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, ChinaBIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, China; Environmental Research Group, MRC Centre for Environment and Health, Imperial College London, London, UKBIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, ChinaBIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, China; National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, ChinaInstitute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health and Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, ChinaBIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, China; GRiC, Shenzhen Institute of Building Research Co., Ltd., Shenzhen, ChinaBIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, ChinaBIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, ChinaBIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, ChinaBIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, ChinaBIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, ChinaBIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, ChinaPeking University Hospital, Peking University, Beijing, ChinaBIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, China; Corresponding author.Background: Exposure to ambient air particulate matter (PM) is a risk factor for cardiometabolic diseases. The knowledge of the underlying mechanisms is still evolving, but systemic inflammation and oxidative stress are central to the ability of PM to induce cardiometabolic effects. Oxylipins derived from polyunsaturated fatty acids (PUFAs) are bioactive lipid mediators that have fundamental roles in the signaling of inflammatory events. However, the associations between oxylipins and short-term exposure to PM in humans are unknown. Methods: Using targeted lipidomic analyses, we measured 16 oxylipins derived from lipoxygenase (LOX), cytochrome P450 (CYP), and cyclooxygenase (COX) pathways and their parent PUFAs in serum samples of 110 adults enrolled in a panel study in Beijing, China. Each participant completed 2–7 clinical visits from 2013 to 2015. PM with aerodynamic diameter ≤ 2.5 μm (PM2.5) and ≤ 0.1 μm (ultrafine particles, UFPs) were continuously monitored at a station. Linear mixed-effects models were applied to examine the associations between changes in lipid mediators and exposure to ambient PM during the preceding 1 to 3 days before the clinical visit. Results: Serum concentrations of PUFAs, including omega-6 arachidonic acid (ARA) and omega-3 eicosapentaenoic acid (EPA), were significantly increased in association with interquartile range (IQR) increases in PM with different exposure windows (i.e., 1–3 days). Regarding oxylipins, significant PM-associated changes included increases in LOX-derived leukotriene B4 (LTB4), 12(S)-, 15(S)-hydroxyeicosatetraenoic acid (HETE), 12-hydroxyeicosapentaenoic acid (HEPE), and 17-hydroxydocosahexaenoic acid (HDHA); an increase in CYP-derived 5,6-dihydroxyeicosatrienoic acid (DHET); and a decrease in COX-derived prostaglandin E2. Conclusions: Short-term exposure to PM was associated with PUFAs and oxylipins derived from LOX, CYP, and COX pathways in humans. Our findings provide mechanistic insight suggesting bioactive oxylipins might be used as biomarkers and have important implications as mediators of PM-associated systemic cardiometabolic effects.http://www.sciencedirect.com/science/article/pii/S0160412020322698Particulate matterPUFAsOxylipinsLipoxygenaseCytochrome P450Cyclooxygenase |