Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis?
Objective: Neuroleptic malignant syndrome (NMS) is a rare but severe side effect of antipsychotic medication. Neutrophil-lymphocyte ratio (NLR) is a simple marker used to measure systemic inflammation. Method: In this case report we explore the relationship of inflammation in the etiology of NMS...
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Tehran University of Medical Sciences
2021-06-01
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| Series: | Iranian Journal of Psychiatry |
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| Online Access: | https://ijps.tums.ac.ir/index.php/ijps/article/view/1714 |
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doaj-6325662b5fd045a7a81eedc5647bbd112021-09-11T05:18:59ZengTehran University of Medical SciencesIranian Journal of Psychiatry1735-45872008-22152021-06-0116310.18502/ijps.v16i3.6264Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis?Tevfik Kalelioglu0Guler Celikel1Ozlem Devrim Balaban2Nesrin Karamustafalioglu3Jennifer Kim Penberthy4Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, United States of America.Department of Psychiatry, Bakırköy Mental Health Research and Teaching Hospital, Istanbul, Turkey.Department of Psychiatry, Bakırköy Mental Health Research and Teaching Hospital, Istanbul, Turkey.Department of Psychiatry, Bakırköy Mental Health Research and Teaching Hospital, Istanbul, Turkey.Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, United States of America. Objective: Neuroleptic malignant syndrome (NMS) is a rare but severe side effect of antipsychotic medication. Neutrophil-lymphocyte ratio (NLR) is a simple marker used to measure systemic inflammation. Method: In this case report we explore the relationship of inflammation in the etiology of NMS. In our case involving NMS, although there was no leukocytosis, the NLR was increased up to systemic infection levels. Conclusion: We hypothesized that systemic inflammation may take a role in developing NMS. If so, NLR could be a new marker of NMS that may be able to provide more sensitive results than leukocyte levels. https://ijps.tums.ac.ir/index.php/ijps/article/view/1714Antipsychotic AgentsInflammationLymphocyteNeuroleptic Malignant SyndromeNeutrophil |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Tevfik Kalelioglu Guler Celikel Ozlem Devrim Balaban Nesrin Karamustafalioglu Jennifer Kim Penberthy |
| spellingShingle |
Tevfik Kalelioglu Guler Celikel Ozlem Devrim Balaban Nesrin Karamustafalioglu Jennifer Kim Penberthy Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis? Iranian Journal of Psychiatry Antipsychotic Agents Inflammation Lymphocyte Neuroleptic Malignant Syndrome Neutrophil |
| author_facet |
Tevfik Kalelioglu Guler Celikel Ozlem Devrim Balaban Nesrin Karamustafalioglu Jennifer Kim Penberthy |
| author_sort |
Tevfik Kalelioglu |
| title |
Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis? |
| title_short |
Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis? |
| title_full |
Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis? |
| title_fullStr |
Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis? |
| title_full_unstemmed |
Can Neutrophil-Lymphocyte Ratio Be a Useful Criterion for Neuroleptic Malignant Syndrome in the Absence of Leukocytosis? |
| title_sort |
can neutrophil-lymphocyte ratio be a useful criterion for neuroleptic malignant syndrome in the absence of leukocytosis? |
| publisher |
Tehran University of Medical Sciences |
| series |
Iranian Journal of Psychiatry |
| issn |
1735-4587 2008-2215 |
| publishDate |
2021-06-01 |
| description |
Objective: Neuroleptic malignant syndrome (NMS) is a rare but severe side effect of antipsychotic medication. Neutrophil-lymphocyte ratio (NLR) is a simple marker used to measure systemic inflammation.
Method: In this case report we explore the relationship of inflammation in the etiology of NMS. In our case involving NMS, although there was no leukocytosis, the NLR was increased up to systemic infection levels.
Conclusion: We hypothesized that systemic inflammation may take a role in developing NMS. If so, NLR could be a new marker of NMS that may be able to provide more sensitive results than leukocyte levels.
|
| topic |
Antipsychotic Agents Inflammation Lymphocyte Neuroleptic Malignant Syndrome Neutrophil |
| url |
https://ijps.tums.ac.ir/index.php/ijps/article/view/1714 |
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