Advances in Fungal Peptide Vaccines
Vaccination is one of the greatest public health achievements in the past century, protecting and improving the quality of life of the population worldwide. However, a safe and effective vaccine for therapeutic or prophylactic treatment of fungal infections is not yet available. The lack of a vaccin...
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doaj-632bbbe55b004b29b9641b490bd299152020-11-25T03:51:39ZengMDPI AGJournal of Fungi2309-608X2020-07-01611911910.3390/jof6030119Advances in Fungal Peptide VaccinesLeandro B. R. Da Silva0Carlos P. Taborda1Joshua D. Nosanchuk2Instituto de Ciencias Biomedicas, Departamento de Microbiologia, Universidade de Sao Paulo, Sao Paulo 05508-000, BrazilInstituto de Ciencias Biomedicas, Departamento de Microbiologia, Universidade de Sao Paulo, Sao Paulo 05508-000, BrazilDepartments of Medicine (Division of Infectious Diseases) and Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USAVaccination is one of the greatest public health achievements in the past century, protecting and improving the quality of life of the population worldwide. However, a safe and effective vaccine for therapeutic or prophylactic treatment of fungal infections is not yet available. The lack of a vaccine for fungi is a problem of increasing importance as the incidence of diverse species, including <i>Paracoccidioides, Aspergillus, Candida, Sporothrix</i>, and <i>Coccidioides</i>, has increased in recent decades and new drug-resistant pathogenic fungi are emerging. In fact, our antifungal armamentarium too frequently fails to effectively control or cure mycoses, leading to high rates of mortality and morbidity. With this in mind, many groups are working towards identifying effective and safe vaccines for fungal pathogens, with a particular focus of generating vaccines that will work in individuals with compromised immunity who bear the major burden of infections from these microbes. In this review, we detail advances in the development of vaccines for pathogenic fungi, and highlight new methodologies using immunoproteomic techniques and bioinformatic tools that have led to new vaccine formulations, like peptide-based vaccines.https://www.mdpi.com/2309-608X/6/3/119fungalvaccinepeptides<i>paracoccidioides</i><i>sporothrix</i><i>aspergillus</i> |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Leandro B. R. Da Silva Carlos P. Taborda Joshua D. Nosanchuk |
spellingShingle |
Leandro B. R. Da Silva Carlos P. Taborda Joshua D. Nosanchuk Advances in Fungal Peptide Vaccines Journal of Fungi fungal vaccine peptides <i>paracoccidioides</i> <i>sporothrix</i> <i>aspergillus</i> |
author_facet |
Leandro B. R. Da Silva Carlos P. Taborda Joshua D. Nosanchuk |
author_sort |
Leandro B. R. Da Silva |
title |
Advances in Fungal Peptide Vaccines |
title_short |
Advances in Fungal Peptide Vaccines |
title_full |
Advances in Fungal Peptide Vaccines |
title_fullStr |
Advances in Fungal Peptide Vaccines |
title_full_unstemmed |
Advances in Fungal Peptide Vaccines |
title_sort |
advances in fungal peptide vaccines |
publisher |
MDPI AG |
series |
Journal of Fungi |
issn |
2309-608X |
publishDate |
2020-07-01 |
description |
Vaccination is one of the greatest public health achievements in the past century, protecting and improving the quality of life of the population worldwide. However, a safe and effective vaccine for therapeutic or prophylactic treatment of fungal infections is not yet available. The lack of a vaccine for fungi is a problem of increasing importance as the incidence of diverse species, including <i>Paracoccidioides, Aspergillus, Candida, Sporothrix</i>, and <i>Coccidioides</i>, has increased in recent decades and new drug-resistant pathogenic fungi are emerging. In fact, our antifungal armamentarium too frequently fails to effectively control or cure mycoses, leading to high rates of mortality and morbidity. With this in mind, many groups are working towards identifying effective and safe vaccines for fungal pathogens, with a particular focus of generating vaccines that will work in individuals with compromised immunity who bear the major burden of infections from these microbes. In this review, we detail advances in the development of vaccines for pathogenic fungi, and highlight new methodologies using immunoproteomic techniques and bioinformatic tools that have led to new vaccine formulations, like peptide-based vaccines. |
topic |
fungal vaccine peptides <i>paracoccidioides</i> <i>sporothrix</i> <i>aspergillus</i> |
url |
https://www.mdpi.com/2309-608X/6/3/119 |
work_keys_str_mv |
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