Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo
Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a complicated process called melanogenesis that is catalyzed by tyrosinase and other tyrosinase-related proteins. The abnormal loss of melanin causes dermatological problems...
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doaj-63363ef192d44ea5b3d97b6556d5fcdb2020-11-24T21:27:50ZengMDPI AGMolecules1420-30492017-08-01228130310.3390/molecules22081303molecules22081303Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for VitiligoChao Niu0Haji A. Aisa1Key Laboratory of Plant Resources and Chemistry of Arid Zone, Chinese Academy of Sciences, Urumqi 830011, ChinaKey Laboratory of Plant Resources and Chemistry of Arid Zone, Chinese Academy of Sciences, Urumqi 830011, ChinaMelanin, the compound primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a complicated process called melanogenesis that is catalyzed by tyrosinase and other tyrosinase-related proteins. The abnormal loss of melanin causes dermatological problems such as vitiligo. Hence the regulation of melanogenesis and tyrosinase activity is very important for treating hypopigmentary disorders. Many melanogenesis stimulators have been discovered during the past decade. This article reviews recent advances in research on extracts and active ingredients of plants, synthesized compounds with stimulating effect on melanin synthesis and tyrosinase activity, as well as their influence on the expression of related proteins and possible signaling pathways for the design and development of novel anti-vitiligo agents.https://www.mdpi.com/1420-3049/22/8/1303melanogenesistyrosinase activityvitiligoplant extractsnatural productssynthesized derivativesanalogues |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chao Niu Haji A. Aisa |
spellingShingle |
Chao Niu Haji A. Aisa Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo Molecules melanogenesis tyrosinase activity vitiligo plant extracts natural products synthesized derivatives analogues |
author_facet |
Chao Niu Haji A. Aisa |
author_sort |
Chao Niu |
title |
Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo |
title_short |
Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo |
title_full |
Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo |
title_fullStr |
Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo |
title_full_unstemmed |
Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo |
title_sort |
upregulation of melanogenesis and tyrosinase activity: potential agents for vitiligo |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2017-08-01 |
description |
Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a complicated process called melanogenesis that is catalyzed by tyrosinase and other tyrosinase-related proteins. The abnormal loss of melanin causes dermatological problems such as vitiligo. Hence the regulation of melanogenesis and tyrosinase activity is very important for treating hypopigmentary disorders. Many melanogenesis stimulators have been discovered during the past decade. This article reviews recent advances in research on extracts and active ingredients of plants, synthesized compounds with stimulating effect on melanin synthesis and tyrosinase activity, as well as their influence on the expression of related proteins and possible signaling pathways for the design and development of novel anti-vitiligo agents. |
topic |
melanogenesis tyrosinase activity vitiligo plant extracts natural products synthesized derivatives analogues |
url |
https://www.mdpi.com/1420-3049/22/8/1303 |
work_keys_str_mv |
AT chaoniu upregulationofmelanogenesisandtyrosinaseactivitypotentialagentsforvitiligo AT hajiaaisa upregulationofmelanogenesisandtyrosinaseactivitypotentialagentsforvitiligo |
_version_ |
1725973046837116928 |