Long-term risk of primary liver cancers in entecavir versus tenofovir treatment for chronic hepatitis B
Abstract It remains controversial whether entecavir (ETV) and tenofovir disoproxil fumarate (TDF) is associated with different clinical outcomes for chronic hepatitis B (CHB). This study aimed to compare the long-term risk of ETV versus TDF on hepatocellular carcinoma (HCC) and intrahepatic cholangi...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-01-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-80523-7 |
id |
doaj-6340c65cb8884b2bb678908fe63e8626 |
---|---|
record_format |
Article |
spelling |
doaj-6340c65cb8884b2bb678908fe63e86262021-01-17T12:36:20ZengNature Publishing GroupScientific Reports2045-23222021-01-0111111410.1038/s41598-020-80523-7Long-term risk of primary liver cancers in entecavir versus tenofovir treatment for chronic hepatitis BTe-Sheng Chang0Yao-Hsu Yang1Wei-Ming Chen2Chien-Heng Shen3Shui-Yi Tung4Chih-Wei Yen5Yung-Yu Hsieh6Chuan-Pin Lee7Meng-Ling Tsai8Chao-Hung Hung9Sheng-Nan Lu10Division of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial HospitalDepartment of Traditional Chinese Medicine, Chiayi Chang Gung Memorial HospitalDivision of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial HospitalDivision of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial HospitalDivision of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial HospitalDivision of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial HospitalDivision of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial HospitalDepartment of Traditional Chinese Medicine, Chiayi Chang Gung Memorial HospitalDepartment of Traditional Chinese Medicine, Chiayi Chang Gung Memorial HospitalDivision of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial HospitalDivision of Hepatogastroenterology, Department of Internal Medicine, Chiayi Chang Gung Memorial HospitalAbstract It remains controversial whether entecavir (ETV) and tenofovir disoproxil fumarate (TDF) is associated with different clinical outcomes for chronic hepatitis B (CHB). This study aimed to compare the long-term risk of ETV versus TDF on hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) in CHB patients from a large multi-institutional database in Taiwan. From 2011 to 2018, a total of 21,222 CHB patients receiving ETV or TDF were screened for eligibility. Patients with coinfection, preexisting cancer and less than 6 months of follow-up were excluded. Finally, 7248 patients (5348 and 1900 in the ETV and TDF groups, respectively) were linked to the National Cancer Registry database for the development of HCC or ICC. Propensity score matching (PSM) (2:1) analysis was used to adjust for baseline differences. The HCC incidence between two groups was not different in the entire population (hazard ratio [HR] 0.82; 95% confidence interval [CI] 0.66–1.02, p = 0.078) and in the PSM population (HR 0.83; 95% CI 0.65–1.06, p = 0.129). Among decompensated cirrhotic patients, a lower risk of HCC was observed in TDF group than in ETV group (HR 0.54; 95% CI 0.30–0.98, p = 0.043, PSM model). There were no differences between ETV and TDF groups in the ICC incidence (HR 1.84; 95% CI 0.54–6.29, p = 0.330 in the entire population and HR 1.04; 95% CI 0.31–3.52, p = 0.954 in the PSM population, respectively). In conclusion, treatment with ETV and TDF showed a comparable long-term risk of HCC and ICC in CHB patients.https://doi.org/10.1038/s41598-020-80523-7 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Te-Sheng Chang Yao-Hsu Yang Wei-Ming Chen Chien-Heng Shen Shui-Yi Tung Chih-Wei Yen Yung-Yu Hsieh Chuan-Pin Lee Meng-Ling Tsai Chao-Hung Hung Sheng-Nan Lu |
spellingShingle |
Te-Sheng Chang Yao-Hsu Yang Wei-Ming Chen Chien-Heng Shen Shui-Yi Tung Chih-Wei Yen Yung-Yu Hsieh Chuan-Pin Lee Meng-Ling Tsai Chao-Hung Hung Sheng-Nan Lu Long-term risk of primary liver cancers in entecavir versus tenofovir treatment for chronic hepatitis B Scientific Reports |
author_facet |
Te-Sheng Chang Yao-Hsu Yang Wei-Ming Chen Chien-Heng Shen Shui-Yi Tung Chih-Wei Yen Yung-Yu Hsieh Chuan-Pin Lee Meng-Ling Tsai Chao-Hung Hung Sheng-Nan Lu |
author_sort |
Te-Sheng Chang |
title |
Long-term risk of primary liver cancers in entecavir versus tenofovir treatment for chronic hepatitis B |
title_short |
Long-term risk of primary liver cancers in entecavir versus tenofovir treatment for chronic hepatitis B |
title_full |
Long-term risk of primary liver cancers in entecavir versus tenofovir treatment for chronic hepatitis B |
title_fullStr |
Long-term risk of primary liver cancers in entecavir versus tenofovir treatment for chronic hepatitis B |
title_full_unstemmed |
Long-term risk of primary liver cancers in entecavir versus tenofovir treatment for chronic hepatitis B |
title_sort |
long-term risk of primary liver cancers in entecavir versus tenofovir treatment for chronic hepatitis b |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-01-01 |
description |
Abstract It remains controversial whether entecavir (ETV) and tenofovir disoproxil fumarate (TDF) is associated with different clinical outcomes for chronic hepatitis B (CHB). This study aimed to compare the long-term risk of ETV versus TDF on hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) in CHB patients from a large multi-institutional database in Taiwan. From 2011 to 2018, a total of 21,222 CHB patients receiving ETV or TDF were screened for eligibility. Patients with coinfection, preexisting cancer and less than 6 months of follow-up were excluded. Finally, 7248 patients (5348 and 1900 in the ETV and TDF groups, respectively) were linked to the National Cancer Registry database for the development of HCC or ICC. Propensity score matching (PSM) (2:1) analysis was used to adjust for baseline differences. The HCC incidence between two groups was not different in the entire population (hazard ratio [HR] 0.82; 95% confidence interval [CI] 0.66–1.02, p = 0.078) and in the PSM population (HR 0.83; 95% CI 0.65–1.06, p = 0.129). Among decompensated cirrhotic patients, a lower risk of HCC was observed in TDF group than in ETV group (HR 0.54; 95% CI 0.30–0.98, p = 0.043, PSM model). There were no differences between ETV and TDF groups in the ICC incidence (HR 1.84; 95% CI 0.54–6.29, p = 0.330 in the entire population and HR 1.04; 95% CI 0.31–3.52, p = 0.954 in the PSM population, respectively). In conclusion, treatment with ETV and TDF showed a comparable long-term risk of HCC and ICC in CHB patients. |
url |
https://doi.org/10.1038/s41598-020-80523-7 |
work_keys_str_mv |
AT teshengchang longtermriskofprimarylivercancersinentecavirversustenofovirtreatmentforchronichepatitisb AT yaohsuyang longtermriskofprimarylivercancersinentecavirversustenofovirtreatmentforchronichepatitisb AT weimingchen longtermriskofprimarylivercancersinentecavirversustenofovirtreatmentforchronichepatitisb AT chienhengshen longtermriskofprimarylivercancersinentecavirversustenofovirtreatmentforchronichepatitisb AT shuiyitung longtermriskofprimarylivercancersinentecavirversustenofovirtreatmentforchronichepatitisb AT chihweiyen longtermriskofprimarylivercancersinentecavirversustenofovirtreatmentforchronichepatitisb AT yungyuhsieh longtermriskofprimarylivercancersinentecavirversustenofovirtreatmentforchronichepatitisb AT chuanpinlee longtermriskofprimarylivercancersinentecavirversustenofovirtreatmentforchronichepatitisb AT menglingtsai longtermriskofprimarylivercancersinentecavirversustenofovirtreatmentforchronichepatitisb AT chaohunghung longtermriskofprimarylivercancersinentecavirversustenofovirtreatmentforchronichepatitisb AT shengnanlu longtermriskofprimarylivercancersinentecavirversustenofovirtreatmentforchronichepatitisb |
_version_ |
1714941822202019840 |