Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer
Ovarian cancer is a highly deadly malignancy in which recurrence is considered incurable. Resistance to platinum-based chemotherapy bodes a particularly abysmal prognosis, underscoring the need for novel therapeutic agents and strategies. The use of mithramycin, an antineoplastic antibiotic, has bee...
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doaj-63441dc373524a2db863d33e0a46b78f2021-01-13T00:04:05ZengMDPI AGBiomedicines2227-90592021-01-019707010.3390/biomedicines9010070Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian CancerDavid Schweer0J. Robert McCorkle1Jurgen Rohr2Oleg V. Tsodikov3Frederick Ueland4Jill Kolesar5Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Lexington, University of Kentucky Markey Cancer Center, Lexington, KY 40536, USADepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USADepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USADepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USADepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology Lexington, University of Kentucky Markey Cancer Center, Lexington, KY 40536, USADepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology Lexington, University of Kentucky Markey Cancer Center, Lexington, KY 40536, USAOvarian cancer is a highly deadly malignancy in which recurrence is considered incurable. Resistance to platinum-based chemotherapy bodes a particularly abysmal prognosis, underscoring the need for novel therapeutic agents and strategies. The use of mithramycin, an antineoplastic antibiotic, has been previously limited by its narrow therapeutic window. Recent advances in semisynthetic methods have led to mithramycin analogs with improved pharmacological profiles. Mithramycin inhibits the activity of the transcription factor Sp1, which is closely linked with ovarian tumorigenesis and platinum-resistance. This article summarizes recent clinical developments related to mithramycin and postulates a role for the use of mithramycin, or its analog, in the treatment of platinum-resistant ovarian cancer.https://www.mdpi.com/2227-9059/9/1/70ovarian cancermithramycinSp1novel therapeuticsplatinum-resistant |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David Schweer J. Robert McCorkle Jurgen Rohr Oleg V. Tsodikov Frederick Ueland Jill Kolesar |
spellingShingle |
David Schweer J. Robert McCorkle Jurgen Rohr Oleg V. Tsodikov Frederick Ueland Jill Kolesar Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer Biomedicines ovarian cancer mithramycin Sp1 novel therapeutics platinum-resistant |
author_facet |
David Schweer J. Robert McCorkle Jurgen Rohr Oleg V. Tsodikov Frederick Ueland Jill Kolesar |
author_sort |
David Schweer |
title |
Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer |
title_short |
Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer |
title_full |
Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer |
title_fullStr |
Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer |
title_full_unstemmed |
Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer |
title_sort |
mithramycin and analogs for overcoming cisplatin resistance in ovarian cancer |
publisher |
MDPI AG |
series |
Biomedicines |
issn |
2227-9059 |
publishDate |
2021-01-01 |
description |
Ovarian cancer is a highly deadly malignancy in which recurrence is considered incurable. Resistance to platinum-based chemotherapy bodes a particularly abysmal prognosis, underscoring the need for novel therapeutic agents and strategies. The use of mithramycin, an antineoplastic antibiotic, has been previously limited by its narrow therapeutic window. Recent advances in semisynthetic methods have led to mithramycin analogs with improved pharmacological profiles. Mithramycin inhibits the activity of the transcription factor Sp1, which is closely linked with ovarian tumorigenesis and platinum-resistance. This article summarizes recent clinical developments related to mithramycin and postulates a role for the use of mithramycin, or its analog, in the treatment of platinum-resistant ovarian cancer. |
topic |
ovarian cancer mithramycin Sp1 novel therapeutics platinum-resistant |
url |
https://www.mdpi.com/2227-9059/9/1/70 |
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